Quinolones: Difference between revisions
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*Topoisomerase IV<ref name='PMID:8524852'/> | *Topoisomerase IV<ref name='PMID:8524852'/> | ||
**inhibition by norfloxacin reduces activity to a rate of 1/100 the normal level<ref name='PMID:7590259'/> | **inhibition by norfloxacin reduces activity to a rate of 1/100 the normal level<ref name='PMID:7590259'/> | ||
Results in replication fork collapse and induction of the SOS response due to permanent double-stranded breaks caused by the formation of poisonous protein:DNA adducts. | |||
==Resistant Alleles== | ==Resistant Alleles== | ||
Revision as of 15:32, 9 July 2010
Targets
Type II Topoisomerases
- DNA Gyrase
- Topoisomerase IV[1]
- inhibition by norfloxacin reduces activity to a rate of 1/100 the normal level[2]
Results in replication fork collapse and induction of the SOS response due to permanent double-stranded breaks caused by the formation of poisonous protein:DNA adducts.
Resistant Alleles
- ParC
Usage Examples and Notes
- Norfloxacin[3]
References
See Help:References for how to manage references in EcoliWiki.
- ↑ Khodursky, AB et al. (1995) Topoisomerase IV is a target of quinolones in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 92 11801-5 PubMed
- ↑ Zechiedrich, EL & Cozzarelli, NR (1995) Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. Genes Dev. 9 2859-69 PubMed
- ↑ Lopez, CR et al. (2005) A role for topoisomerase III in a recombination pathway alternative to RuvABC. Mol. Microbiol. 58 80-101 PubMed