Quinolones: Difference between revisions

Revision as of 15:28, 9 July 2010

Binds to Topoisomerase IV and DNA Gyrase to form poisonous adducts on the DNA.

Type II Topoisomerases

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↑ Khodursky, AB et al. (1995) Topoisomerase IV is a target of quinolones in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 92 11801-5 PubMed
↑ Lopez, CR et al. (2005) A role for topoisomerase III in a recombination pathway alternative to RuvABC. Mol. Microbiol. 58 80-101 PubMed

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 ==Resistant Alleles==
 *ParC
-**wtTopo IV inhibition by norfloxacin reduces its activity to a rate of 1/100 the normal level<ref name='PMID:7590259'/>.
 ==Usage Examples and Notes==