Quinolones: Difference between revisions
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==Resistant Alleles== | ==Resistant Alleles== | ||
*ParC | |||
**wtTopo IV inhibition by norfloxacin reduces its activity to a rate of 1/100 the normal level<ref name='PMID:7590259'/>. | |||
==Usage Examples and Notes== | ==Usage Examples and Notes== | ||
Revision as of 15:25, 9 July 2010
About
Binds to Topoisomerase IV and DNA Gyrase to form poisonous adducts on the DNA.
Resistant Alleles
- ParC
- wtTopo IV inhibition by norfloxacin reduces its activity to a rate of 1/100 the normal level[1].
Usage Examples and Notes
- Norfloxacin[2]
References
See Help:References for how to manage references in EcoliWiki.
- ↑ Zechiedrich, EL & Cozzarelli, NR (1995) Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. Genes Dev. 9 2859-69 PubMed
- ↑ Lopez, CR et al. (2005) A role for topoisomerase III in a recombination pathway alternative to RuvABC. Mol. Microbiol. 58 80-101 PubMed