sucB:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Function from GO
!align=left {{table_heading_style}} |Function from GO
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'''Cellular Component'''
<GO_nr />
* GO:0045252 oxoglutarate dehydrogenase complex ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0006099 tricarboxylic acid cycle ([http://www.geneontology.org/GO.evidence.shtml IMP])
'''Molecular Function'''
* GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity ([http://www.geneontology.org/GO.evidence.shtml IMP,IDA])
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0031405 lipoic acid binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0005488 binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype

Revision as of 19:28, 2 February 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

sucB

Gene Synonym(s)

ECK0715, b0727, JW0716, lys, met[1]

Product Desc.

SucB-lipoate[2][3]

SucB-S-succinyldihydrolipoate

2-oxoglutarate dehydrogenase, E2 component; dihydrolipoamide succinyltransferase; acid-inducible; yields succinyl-CoA and CO(2)[4]

Product Synonyms(s)

dihydrolipoyl transsuccinase[1], B0727[2][1]

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): sdhCDAB-sucABCD[2], OP00142, sdhCDAB, sucABCD[2], OP00143, suc

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(sucB)    Textpresso(sucB)

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See Help:Quickview for help with entering information in the Quickview table.

Notes

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sucAB is a synthetic lethal with sucCD. Residues 104-153 is the E3(Lpd) component binding domain, called the peripheral subunit binding domain (PSBD). When the isolated 50 aa PSBD domain is produced as a protein it is called BBL, which is structuerd at low temperature and may be an example of a downhill protein folding (Packman, 1986; Garcia-Mira, 2002). This controversial topic, centered around experiments with a naphthyl-alanine derivative of BBL termed Naf-BBL, has a topic page with additional citations.[4]



References

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  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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