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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''alkB''  
''alkB''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK2204, b2212, JW2200, aidD''<ref name='LIB:Riley_2006'/>
''ECK2204, b2212, JW2200, aidD''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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AlkB repair system for alkylated DNA and RNA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
AlkB repair system for alkylated DNA and RNA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
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Alkylated DNA repair enzyme; alpha-ketoglutarate- and Fe(II)-dependent dioxygenase; releases replication blocks by oxidative demethylation of 1-methyladenine and 3-methylcytosine residues in ssDNA and dsDNA<ref name='LIB:EcoGene'/>
Alkylated DNA repair enzyme; alpha-ketoglutarate- and Fe(II)-dependent dioxygenase; releases replication blocks by oxidative demethylation of 1-methyladenine and 3-methylcytosine residues in ssDNA and dsDNA<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions<ref name='LIB:Riley_2006'/>, B2212<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AidD<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AlkB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions<ref name='LIB:Riley_2006'/>, B2212<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AidD<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AlkB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Biological Process'''
* GO:0006281 DNA repair ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0006307 DNA dealkylation ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0006974 response to DNA damage stimulus ([http://www.geneontology.org/GO.evidence.shtml IMP])
'''Molecular Function'''
* GO:0008198 ferrous iron binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0051213 dioxygenase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:ada-alkB|ada-alkB]]<ref name='LIB:EcoCyc10.6'/>, OP00100, [[:Category:Txn_unit:alkB|alkB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:ada-alkB|ada-alkB]]<ref name='LIB:EcoCyc10.6'/>, OP00100, [[:Category:Txn_unit:alkB|alkB]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=alkB&loc=MG1655:2307363..2306713,W3110:2312675..2312025,REL606:2259445..2258795,DH10B:2398351..2397701 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2398351&end=2397701&gene=alkB&aa=mldlfadaepwqeplaagavilrrfafnaaeqlirdindvasqspfrqmvtpggytmsvamtncghlgwtthrqgylyspidpqtnkpwpampqsfhnlcqraataagypdfqpdaclinryapgaklslhqdkdepdlrapivsvslglpaifqfgglkrndplkrlllehgdvvvwggesrlfyhgiqplkagfhpltidcrynltfrqagkke Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=alkB+AND+escherichia+coli Pubmed(alkB)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=alkB Textpresso(alkB)]


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Revision as of 00:12, 22 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

alkB

Gene Synonym(s)

ECK2204, b2212, JW2200, aidD[1]

Product Desc.

AlkB repair system for alkylated DNA and RNA[2][3]

Alkylated DNA repair enzyme; alpha-ketoglutarate- and Fe(II)-dependent dioxygenase; releases replication blocks by oxidative demethylation of 1-methyladenine and 3-methylcytosine residues in ssDNA and dsDNA[4]

Product Synonyms(s)

oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions[1], B2212[2][1], AidD[2][1], AlkB[2][1]

Function from GO

Biological Process

Molecular Function

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ada-alkB[2], OP00100, alkB[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(alkB)    Textpresso(alkB)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


AlkB mutants are extremely sensitive to MMS. Also repairs alkylated mRNA and tRNA in vivo and in vitro, the first example of direct RNA repair. Repairs epsilonA and epsilonC. Ada regulon.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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