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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''mtgA''  
''mtgA''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK3197, b3208, JW3175, yrbM, mgt''<ref name='LIB:Riley_2006'/>
''ECK3197, b3208, JW3175, yrbM, mgt''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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biosynthetic peptidoglycan transglycosylase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
biosynthetic peptidoglycan transglycosylase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
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Monofunctional peptidoglycan glycosyltransferase; monofunctional biosynthetic peptidoglycan transglycosylase; GTase; TGase<ref name='LIB:EcoGene'/>
Monofunctional peptidoglycan glycosyltransferase; monofunctional biosynthetic peptidoglycan transglycosylase; GTase; TGase<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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biosynthetic peptidoglycan transglycosylase<ref name='LIB:Riley_2006'/>, B3208<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Mgt<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YrbM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MtgA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
biosynthetic peptidoglycan transglycosylase<ref name='LIB:Riley_2006'/>, B3208<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Mgt<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YrbM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MtgA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Cellular Component'''
* GO:0000299 integral to membrane of membrane fraction ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0043164 Gram-negative-bacterium-type cell wall biogenesis ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Molecular Function'''
* GO:0008955 peptidoglycan glycosyltransferase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IGI])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:mtgA|mtgA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:mtgA|mtgA]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=mtgA&loc=MG1655:3347831..3347103,W3110:3349664..3348936,DH10B:3445576..3444848,REL606:3285044..3284316 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3285044&end=3284316&gene=mtgA&aa=msksrltvfsfvrrfllrlmvvlavfwgggialfsvapvpfsavmverqvsawlhgnfryvahsdwvsmdqispwmglaviaaedqkfpehwgfdvasiekalahnernenrirgastisqqtaknlflwdgrswvrkgleagltlgietvwskkriltvylniaefgdgvfgveaaaqryfhkpaskltrseaallaavlpnplrfkvsspsgyvrsrqawilrqmyqlggepfmqqhqld Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=mtgA+AND+escherichia+coli Pubmed(mtgA)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=mtgA Textpresso(mtgA)]


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Revision as of 23:41, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

mtgA

Gene Synonym(s)

ECK3197, b3208, JW3175, yrbM, mgt[1]

Product Desc.

biosynthetic peptidoglycan transglycosylase[2][3]

Monofunctional peptidoglycan glycosyltransferase; monofunctional biosynthetic peptidoglycan transglycosylase; GTase; TGase[4]

Product Synonyms(s)

biosynthetic peptidoglycan transglycosylase[1], B3208[2][1], Mgt[2][1], YrbM[2][1], MtgA[2][1]

Function from GO

Cellular Component

Biological Process

  • GO:0043164 Gram-negative-bacterium-type cell wall biogenesis (IDA)

Molecular Function

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): mtgA[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(mtgA)    Textpresso(mtgA)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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MtgA has flavomycin-resistant peptidoglycan synthesis activity (Di Berardino, 1996 [5]; Derouaux, 2007). mtgA is a non-essential gene (Schiffer, 1999). MtgA localizes to the division site and interacts with FtsW, FtsN, and FtsI in mcrA(Ts) mrcB- strains, indicating a role for MtgA in peptidoglycan synthesis related to the cell cycle (Derouaux, 2007). The use of the term transglycolase is ambiguous as it can describe both lytic and synthetic peptidoglycan activities, therefore glycosyltransferase is preferred (Di Berardino, 1996). MtgA lacks a penicillin binding domain and therefore is penicillin-insensitive. MtgA is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor (Di Berardino, 1996). MtgA may be the glycan polymerase characterized by Hara (1984), although it has an apparent MW larger than MtgA (Di Berardino, 1996).[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Di Berardino, M et al. (1996) The monofunctional glycosyltransferase of Escherichia coli is a member of a new class of peptidoglycan-synthesising enzymes. FEBS Lett. 392 184-8 PubMed
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