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!align=left {{table_heading_style}} |Standard Name
!align=left |Standard Name
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''hha''  
''hha''  
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!align=left {{table_heading_style}} |Gene Synonym(s)
!align=left |Gene Synonym(s)
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''ECK0454, b0460, JW0449''<ref name='LIB:Riley_2006'/>
''ECK0454, b0460, JW0449''<ref name='LIB:Riley_2006'/>
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!align=left {{table_heading_style}} |Product Desc.
!align=left |Product Desc.
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haemolysin expression modulating protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
haemolysin expression modulating protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
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Hha is a small transcriptional regulator (8 kDa) that is induced in biofilms<ref name='PMID:14727089'/> and that influences biofilm formation<ref name='PMID:16317765'/>; Hha overexpression reduces biofilm formation by increasing biofilm dispersal<ref name='PMID:18545668'/>.  Rather than binding to specific DNA sequences, Hha exhibits non-specific DNA binding.  Hha binds in vivo to 15 genes or intergenic regions of CP4-57 and DLP12 including regions close to the prophage attachment (att) sites and that Hha activates the prophage lytic genes ''alpA'', ''rzpD'', ''appY'' and ''yfjZ'', as well as induces plaque formation and decreases cell viability<ref name='PMID:18545668'/>.
Hha is a small transcriptional regulator (8 kDa) that is induced in biofilms<ref name='PMID:14727089'/> and that influences biofilm formation<ref name='PMID:16317765'/>; Hha overexpression reduces biofilm formation by increasing biofilm dispersal<ref name='PMID:18545668'/>.  Rather than binding to specific DNA sequences, Hha exhibits non-specific DNA binding.  Hha binds in vivo to 15 genes or intergenic regions of CP4-57 and DLP12 including regions close to the prophage attachment (att) sites and that Hha activates the prophage lytic genes ''alpA'', ''rzpD'', ''appY'' and ''yfjZ'', as well as induces plaque formation and decreases cell viability<ref name='PMID:18545668'/>.
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!align=left {{table_heading_style}} |Product Synonyms(s)
!align=left |Product Synonyms(s)
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modulator of gene expression, with H-NS<ref name='LIB:Riley_2006'/>, B0460<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hha<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
modulator of gene expression, with H-NS<ref name='LIB:Riley_2006'/>, B0460<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hha<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:hha|hha]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:hha|hha]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left |Regulation/Activity
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Revision as of 01:34, 9 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

hha

Gene Synonym(s)

ECK0454, b0460, JW0449[1]

Product Desc.

haemolysin expression modulating protein[2][3]

Modulates hemolysin expression, in complex with H-NS; stimulates transposition events; induced by AI-2 pheromone; promotes conjugation and conjugation-induced biofilms[4]

Hha is a small transcriptional regulator (8 kDa) that is induced in biofilms[5] and that influences biofilm formation[6]; Hha overexpression reduces biofilm formation by increasing biofilm dispersal[7]. Rather than binding to specific DNA sequences, Hha exhibits non-specific DNA binding. Hha binds in vivo to 15 genes or intergenic regions of CP4-57 and DLP12 including regions close to the prophage attachment (att) sites and that Hha activates the prophage lytic genes alpA, rzpD, appY and yfjZ, as well as induces plaque formation and decreases cell viability[7].

Product Synonyms(s)

modulator of gene expression, with H-NS[1], B0460[2][1], Hha[2][1]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): hha[2]

Regulation/Activity


edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


Hha and Cnu are paralogs. The expression of the hly operon of plasmid pHly152 is modulatedby Hha/HN-S. Overexpression of Cnu(YdgT) partially suppresses the hha defect on hylA expression. Hha positively modulates H-NS expression. Induced during biofilm formation.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Ren, D et al. (2004) Gene expression in Escherichia coli biofilms. Appl. Microbiol. Biotechnol. 64 515-24 PubMed
  6. ↑ Barrios, AF et al. (2006) Hha, YbaJ, and OmpA regulate Escherichia coli K12 biofilm formation and conjugation plasmids abolish motility. Biotechnol. Bioeng. 93 188-200 PubMed
  7. ↑ 7.0 7.1 García-Contreras, R et al. (2008) Protein translation and cell death: the role of rare tRNAs in biofilm formation and in activating dormant phage killer genes. PLoS ONE 3 e2394 PubMed
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