hsdS:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Standard Name
!align=left |Standard Name
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''hsdS''  
''hsdS''  
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!align=left {{table_heading_style}} |Gene Synonym(s)
!align=left |Gene Synonym(s)
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''ECK4338, b4348, JW4311, hss, hsp, rm''<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
''ECK4338, b4348, JW4311, hss, hsp, rm''<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
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!align=left {{table_heading_style}} |Product Desc.
!align=left |Product Desc.
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specificity determinant for hsdM and hsdR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
specificity determinant for hsdM and hsdR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Specificity determinant for HsdM and HsdR<ref name='LIB:EcoGene'/>
Specificity determinant for HsdM and HsdR<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
!align=left |Product Synonyms(s)
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specificity determinant for hsdM and hsdR product<ref name='LIB:Riley_2006'/>, B4348 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hss product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hsp product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HsdS product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
specificity determinant for hsdM and hsdR product<ref name='LIB:Riley_2006'/>, B4348 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hss product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hsp product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HsdS product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:hsdMS|hsdMS]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:hsdMS|hsdMS]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left |Regulation/Activity
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Revision as of 01:38, 9 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

hsdS

Gene Synonym(s)

ECK4338, b4348, JW4311, hss, hsp, rm[1][2]

Product Desc.

specificity determinant for hsdM and hsdR[2][3];

Component of [[:Category:Complex:EcoKI restriction-modification system|EcoKI restriction-modification system]][3]

Specificity determinant for HsdM and HsdR[4]

Product Synonyms(s)

specificity determinant for hsdM and hsdR product[1], B4348 product[2][1], Hss product[2][1], Hsp product[2][1], HsdS product[2][1]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): hsdMS[2]

Regulation/Activity


edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

The restriction-modification complex EcoKI is comprised of three polypeptide subunits coded for by the genes hsdS, hsdM, and hsdR. HsdS is the polypeptide that directly interacts with DNA through the use of two target recognition domain (TRD) sequences first isolated by Fuller-Pace and Murray.[5] HsdS recognizes and binds to the nucleotide sequence 5' AAC(N)6GTGC. Fuller-Pace and Murray determined this sequence of the TRDs in hsdS after recombining two homologous hsdS genes from a family of restriction-modification complexes.

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Substitution of Trp212 to Arg alters the protein-protein interaction with HsdM, in turn effecting the DNA binding of the molecule; DNA binding in the mutant is restored by HsdR binding.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Fuller-Pace, FV & Murray, NE (1986) Two DNA recognition domains of the specificity polypeptides of a family of type I restriction enzymes. Proc. Natl. Acad. Sci. U.S.A. 83 9368-72 PubMed
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