hsdS:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[hsdS:Gene|''hsdS]]'' (synonyms: ''ECK4338, b4348, JW4311, hss, hsp, rm'')<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
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!align=left {{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[hsdS:Gene_Product(s)|HsdS product]]<ref name='LIB:Riley_2006'/>: specificity determinant for hsdM and hsdR product, B4348 product, Hss product, Hsp product
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!align=left {{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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specificity determinant for hsdM and hsdR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
!align=left {{table_heading_style}} |Product Synonyms(s)
 
Component of [[:Category:Complex:EcoKI restriction-modification system|EcoKI restriction-modification system]]<ref name='LIB:EcoCyc11.1'/>
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:hsdMS|hsdMS]]<ref name='LIB:EcoCyc10.6'/>
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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Revision as of 20:48, 4 March 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name
Gene Synonym(s)
Product Desc.
Product Synonyms(s)
Knock-Out Phenotype
Regulation/Expression
Regulation/Activity
edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

The restriction-modification complex EcoKI is comprised of three polypeptide subunits coded for by the genes hsdS, hsdM, and hsdR. HsdS is the polypeptide that directly interacts with DNA through the use of two target recognition domain (TRD) sequences first isolated by Fuller-Pace and Murray.[1] HsdS recognizes and binds to the nucleotide sequence 5' AAC(N)6GTGC. Fuller-Pace and Murray determined this sequence of the TRDs in hsdS after recombining two homologous hsdS genes from a family of restriction-modification complexes.

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Substitution of Trp212 to Arg alters the protein-protein interaction with HsdM, in turn effecting the DNA binding of the molecule; DNA binding in the mutant is restored by HsdR binding.[2]



References

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  1. ↑ Fuller-Pace, FV & Murray, NE (1986) Two DNA recognition domains of the specificity polypeptides of a family of type I restriction enzymes. Proc. Natl. Acad. Sci. U.S.A. 83 9368-72 PubMed
  2. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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