asnA:Quickview: Difference between revisions

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===Notes===
===Notes===
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AsnA and AsnB are redundant; an asparagine auxotrophy requires that both genes be mutated. AsnA uses ammonia as the nitrogen source. Residues 199-203 of zwf encode a NNWDN peptide involved in ChpA(MazF) toxicity that is likely converted to NNWNN by AsnA since an asnA deletion prevents NNWNN activity (Kolodkin-Gal, 2007).<ref name='LIB:EcoGene'/>





Revision as of 23:28, 2 March 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Gene Name

asnA (synonyms: ECK3738, b3744, JW3722)[1]

Product(s)

AsnA product[1]: asparagine synthetase A product, B3744 product

Description

AsnA[2][3]

Component of aspartate-ammonia ligase[2]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): asnA[2], OP00152

Regulation/Activity


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Notes

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AsnA and AsnB are redundant; an asparagine auxotrophy requires that both genes be mutated. AsnA uses ammonia as the nitrogen source. Residues 199-203 of zwf encode a NNWDN peptide involved in ChpA(MazF) toxicity that is likely converted to NNWNN by AsnA since an asnA deletion prevents NNWNN activity (Kolodkin-Gal, 2007).[4]



References

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  1. ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.