gadE:Quickview: Difference between revisions

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===Notes===
===Notes===
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GadE overexpression confers acid resistance.  GadE is induced by YdeO overexpression.  GadE is in the EvgAS regulon.  GadE is a LuxR family regulator.  GadE is possibly involved in the regulation of type III secretion systems in enterohemorrhagic E. coli O157:H7. Required for stationary phase-induced, pH 5.5 growth medium-induced, and EvgA-induced acid resistance<ref name='LIB:EcoGene'/>





Revision as of 01:18, 3 March 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Gene Name

gadE (synonyms: ECK3496, b3512, JW3480, yhiE, yhiT)[1]

Product(s)

GadE product[1]: DNA-binding transcriptional activator product, B3512 product, YhiT product, YhiE product, acid-responsive regulator of gadA and gadBC product

Description

GadE transcriptional activator[2][3]

Knock-Out Phenotype

Sensitive to pH below pH 2.5

Regulation/Expression

transcription unit(s): gadE[2]

Regulation/Activity

Activated by EvgA, YdeO, GadX, GadW, GadE, MnmE(indirect?)

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Notes

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GadE overexpression confers acid resistance. GadE is induced by YdeO overexpression. GadE is in the EvgAS regulon. GadE is a LuxR family regulator. GadE is possibly involved in the regulation of type III secretion systems in enterohemorrhagic E. coli O157:H7. Required for stationary phase-induced, pH 5.5 growth medium-induced, and EvgA-induced acid resistance[4]



References

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  1. ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.