Category:Complex:SecEGY-Secretion Complex: Difference between revisions

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==About==
'''Description''' (originally from EcoCyc<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>) SecEGY-Secretion Complex
 
'''Comments''' (originally from EcoCyc<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>) SecE and SecY are inner membrane proteins that are involved in the Sec protein secretion pathway in
<I>E.coli</I>. They were identified as being critical to protein translocation through interaction with SecA
and SecB. Complementation studies showed that conditional lethal mutations in <I>secY</I> resulted in a
defective translocation process <ref name='PMID:6339072'/><ref name='PMID:3284784'/><ref name='PMID:8641431'/><ref name='PMID:11222599'/><ref name='PMID:2167176'/><ref name='PMID:8428583'/><ref name='PMID:15210351'/><ref name='PMID:16242710'/><ref name='PMID:16292303'/><ref name='PMID:15815684'/>.
 
 
==References==
<references/>

Revision as of 12:29, 20 July 2007

About

Description (originally from EcoCyc[1][2]) SecEGY-Secretion Complex

Comments (originally from EcoCyc[1][2]) SecE and SecY are inner membrane proteins that are involved in the Sec protein secretion pathway in E.coli. They were identified as being critical to protein translocation through interaction with SecA and SecB. Complementation studies showed that conditional lethal mutations in secY resulted in a defective translocation process [3][4][5][6][7][8][9][10][11][12].


References

  1. ↑ 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ Ito, K et al. (1983) A temperature-sensitive mutant of E. coli exhibiting slow processing of exported proteins. Cell 32 789-97 PubMed
  4. ↑ Riggs, PD et al. (1988) A mutation affecting the regulation of a secA-lacZ fusion defines a new sec gene. Genetics 118 571-9 PubMed
  5. ↑ Hanada, M et al. (1996) SecG plays a critical role in protein translocation in the absence of the proton motive force as well as at low temperature. FEBS Lett 381 25-8 PubMed
  6. ↑ Flower, AM (2001) SecG function and phospholipid metabolism in Escherichia coli. J Bacteriol 183 2006-12 PubMed
  7. ↑ Brundage, L et al. (1990) The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation. Cell 62 649-57 PubMed
  8. ↑ Joly, JC & Wickner, W (1993) The SecA and SecY subunits of translocase are the nearest neighbors of a translocating preprotein, shielding it from phospholipids. EMBO J 12 255-63 PubMed
  9. ↑ Tziatzios, C et al. (2004) The bacterial protein-translocation complex: SecYEG dimers associate with one or two SecA molecules. J Mol Biol 340 513-24 PubMed
  10. ↑ Scheuring, J et al. (2005) The oligomeric distribution of SecYEG is altered by SecA and translocation ligands. J Mol Biol 354 258-71 PubMed
  11. ↑ Mitra, K et al. (2005) Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature 438 318-24 PubMed
  12. ↑ Angelini, S et al. (2005) FtsY, the bacterial signal-recognition particle receptor, interacts functionally and physically with the SecYEG translocon. EMBO Rep. 6 476-81 PubMed

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