Bicyclomycin: Difference between revisions
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<ref name='PMID:16181146'/> | <ref name='PMID:16181146'/> | ||
===Mode of Action=== | ===Mode of Action=== | ||
Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP. | Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP. | ||
<ref name='PMID:16181146'/> | <ref name='PMID:16181146'/> | ||
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===Mutations that affect sensitivity=== | ===Mutations that affect sensitivity=== | ||
Genes in ''E. coli'' that affect sensitivity to bicyclomycin. | |||
<ref name='PMID:21357484'/ | |||
<protect><!--box uid=63ce1649aab8b3180235b0af7618f667.180696.R4e84956686066--> | <protect><!--box uid=63ce1649aab8b3180235b0af7618f667.180696.R4e84956686066--> | ||
Revision as of 15:16, 6 October 2011
Bicyclomycin discovered in 1972, has a unique structure that differentiates it from all other antibiotics. Currently used to treat nonspecific diarrhea, it has a low toxicity, and no cross-resistance with other antibiotics has yet been found. It is effective against many Gram-negative bacteria. [1]
Mode of Action
Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP. [1]
Structure
Targets
Bicyclomycin targets the transcription termination factor Rho [2]
Mechanisms of Resistance
Mutations that affect sensitivity
Genes in E. coli that affect sensitivity to bicyclomycin. <ref name='PMID:21357484'/
<protect>
| Gene | Allele | Sensitivity to BCM | Reference |
|---|---|---|---|
| edit table |
</protect>
References
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