SAR endolysin: Difference between revisions
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== The SAR Paradigm == | == The SAR Paradigm == | ||
Signal Anchor Release (SAR) endolysins muralytic enzymes encoded by dsDNA phages that infect gram negative hosts. They are signaled to the host cytoplasmic membrane and are anchored there in an inactive conformation. They are maintained in the energized membrane and are released by the depolarization action of the holin. After release, the SAR domain folds into the soluble form of the enzyme, activating it. | |||
== Regulation == | == Regulation == | ||
Revision as of 20:29, 5 October 2011
The SAR Paradigm
Signal Anchor Release (SAR) endolysins muralytic enzymes encoded by dsDNA phages that infect gram negative hosts. They are signaled to the host cytoplasmic membrane and are anchored there in an inactive conformation. They are maintained in the energized membrane and are released by the depolarization action of the holin. After release, the SAR domain folds into the soluble form of the enzyme, activating it.
Regulation
Disulfide Bond Isomerization
Regulation by Dynamic Membrane Topology
Prevalence
Role in Pathogenesis
See also
References
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