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| | !align=left |Citation | ||
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'''No author listed''' (2006) A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. ''Genome Biol.'' '''7''':R63 | |||
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| | !align=left |Abstract | ||
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Recently, approaches have been developed for high-throughput identification of synthetic sick/lethal gene pairs. However, these are only a specific example of the broader phenomenon of epistasis, wherein the presence of one mutation modulates the phenotype of another. We present analysis techniques for generating high-confidence quantitative epistasis scores from measurements made using synthetic genetic array and epistatic miniarray profile (E-MAP) technology, as well as several tools for higher-level analysis of the resulting data that are greatly enhanced by the quantitative score and detection of alleviating interactions. | |||
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!align=left |Links | |||
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16859555 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779568 PMC1779568] | |||
Online version:[http://dx.doi.org/10.1186/gb-2006-7-7-r63 10.1186/gb-2006-7-7-r63] | Online version:[http://dx.doi.org/10.1186/gb-2006-7-7-r63 10.1186/gb-2006-7-7-r63] | ||
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!align=left |Keywords | |||
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Epistasis, Genetic; Mutation; Oligonucleotide Array Sequence Analysis; Phenotype | |||
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==Significance {{HelpIcon|Help:Literature}} == | ==Significance {{HelpIcon|Help:Literature}} == | ||
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Revision as of 18:53, 1 September 2013
| Citation |
No author listed (2006) A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol. 7:R63 |
|---|---|
| Abstract |
Recently, approaches have been developed for high-throughput identification of synthetic sick/lethal gene pairs. However, these are only a specific example of the broader phenomenon of epistasis, wherein the presence of one mutation modulates the phenotype of another. We present analysis techniques for generating high-confidence quantitative epistasis scores from measurements made using synthetic genetic array and epistatic miniarray profile (E-MAP) technology, as well as several tools for higher-level analysis of the resulting data that are greatly enhanced by the quantitative score and detection of alleviating interactions. |
| Links |
PubMed PMC1779568 Online version:10.1186/gb-2006-7-7-r63 |
| Keywords |
Epistasis, Genetic; Mutation; Oligonucleotide Array Sequence Analysis; Phenotype |
| edit table |
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| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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