PMID:21415350: Difference between revisions

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<span style = 'font-size: large'> '''Woods, RJ, Barrick, JE, Cooper, TF, Shrestha, U, Kauth, MR and Lenski, RE'''  (2011) Second-order selection for evolvability in a large Escherichia coli population.''Science'' '''331''':1433-6</span>
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|{{TableHeadingColor}} |'''Abstract''' || <protect>In theory, competition between asexual lineages can lead to second-order selection for greater evolutionary potential. To test this hypothesis, we revived a frozen population of Escherichia coli from a long-term evolution experiment and compared the fitness and ultimate fates of four genetically distinct clones. Surprisingly, two clones with beneficial mutations that would eventually take over the population had significantly lower competitive fitness than two clones with mutations that later went extinct. By replaying evolution many times from these clones, we showed that the eventual winners likely prevailed because they had greater potential for further adaptation. Genetic interactions that reduce the benefit of certain regulatory mutations in the eventual losers appear to explain, at least in part, why they were outcompeted.</protect>
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'''No author listed''' (2011) Second-order selection for evolvability in a large Escherichia coli population. ''Science'' '''331''':1433-6
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!align=left  |Abstract
*  [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21415350 PubMed]
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In theory, competition between asexual lineages can lead to second-order selection for greater evolutionary potential. To test this hypothesis, we revived a frozen population of Escherichia coli from a long-term evolution experiment and compared the fitness and ultimate fates of four genetically distinct clones. Surprisingly, two clones with beneficial mutations that would eventually take over the population had significantly lower competitive fitness than two clones with mutations that later went extinct. By replaying evolution many times from these clones, we showed that the eventual winners likely prevailed because they had greater potential for further adaptation. Genetic interactions that reduce the benefit of certain regulatory mutations in the eventual losers appear to explain, at least in part, why they were outcompeted.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21415350 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176658 PMC3176658]
Online version:[http://dx.doi.org/10.1126/science.1198914 10.1126/science.1198914]
Online version:[http://dx.doi.org/10.1126/science.1198914 10.1126/science.1198914]
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!align=left  |Keywords
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Adaptation, Physiological; Biological Evolution; Epistasis, Genetic; Escherichia coli/genetics; Escherichia coli/physiology; Genes, Bacterial; Genetic Fitness; Genotype; Models, Genetic; Mutation; Selection, Genetic
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==Significance {{HelpIcon|Help:Literature}} ==
==Significance {{HelpIcon|Help:Literature}} ==
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Revision as of 19:12, 1 September 2013

Citation

No author listed (2011) Second-order selection for evolvability in a large Escherichia coli population. Science 331:1433-6

Abstract

In theory, competition between asexual lineages can lead to second-order selection for greater evolutionary potential. To test this hypothesis, we revived a frozen population of Escherichia coli from a long-term evolution experiment and compared the fitness and ultimate fates of four genetically distinct clones. Surprisingly, two clones with beneficial mutations that would eventually take over the population had significantly lower competitive fitness than two clones with mutations that later went extinct. By replaying evolution many times from these clones, we showed that the eventual winners likely prevailed because they had greater potential for further adaptation. Genetic interactions that reduce the benefit of certain regulatory mutations in the eventual losers appear to explain, at least in part, why they were outcompeted.

Links

PubMed PMC3176658 Online version:10.1126/science.1198914

Keywords

Adaptation, Physiological; Biological Evolution; Epistasis, Genetic; Escherichia coli/genetics; Escherichia coli/physiology; Genes, Bacterial; Genetic Fitness; Genotype; Models, Genetic; Mutation; Selection, Genetic

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