Quinolones: Difference between revisions
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==About== | ==About== | ||
Binds to Topoisomerase IV and DNA Gyrase to form poisonous adducts on the DNA. | Binds to Topoisomerase IV and DNA Gyrase to form poisonous adducts on the DNA. | ||
==Targets== | |||
Type II Topoisomerases | |||
*DNA Gyrase | |||
*Topoisomerase IV<ref name='PMID:8524852'/> | |||
==Resistant Alleles== | ==Resistant Alleles== | ||
Revision as of 15:27, 9 July 2010
About
Binds to Topoisomerase IV and DNA Gyrase to form poisonous adducts on the DNA.
Targets
Type II Topoisomerases
- DNA Gyrase
- Topoisomerase IV[1]
Resistant Alleles
- ParC
- wtTopo IV inhibition by norfloxacin reduces its activity to a rate of 1/100 the normal level[2].
Usage Examples and Notes
- Norfloxacin[3]
References
See Help:References for how to manage references in EcoliWiki.
- ↑ Khodursky, AB et al. (1995) Topoisomerase IV is a target of quinolones in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 92 11801-5 PubMed
- ↑ Zechiedrich, EL & Cozzarelli, NR (1995) Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. Genes Dev. 9 2859-69 PubMed
- ↑ Lopez, CR et al. (2005) A role for topoisomerase III in a recombination pathway alternative to RuvABC. Mol. Microbiol. 58 80-101 PubMed