PMID:18366802: Difference between revisions

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<span style = 'font-size: large'> '''Fong, C, Rohmer, L, Radey, M, Wasnick, M and Brittnacher, MJ'''  (2008) PSAT: a web tool to compare genomic neighborhoods of multiple prokaryotic genomes.''BMC Bioinformatics'' '''9''':170</span>
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|{{TableHeadingColor}} |'''Abstract''' || <protect>BACKGROUND: The conservation of gene order among prokaryotic genomes can provide valuable insight into gene function, protein interactions, or events by which genomes have evolved. Although some tools are available for visualizing and comparing the order of genes between genomes of study, few support an efficient and organized analysis between large numbers of genomes. The Prokaryotic Sequence homology Analysis Tool (PSAT) is a web tool for comparing gene neighborhoods among multiple prokaryotic genomes. RESULTS: PSAT utilizes a database that is preloaded with gene annotation, BLAST hit results, and gene-clustering scores designed to help identify regions of conserved gene order. Researchers use the PSAT web interface to find a gene of interest in a reference genome and efficiently retrieve the sequence homologs found in other bacterial genomes. The tool generates a graphic of the genomic neighborhood surrounding the selected gene and the corresponding regions for its homologs in each comparison genome. Homologs in each region are color coded to assist users with analyzing gene order among various genomes. In contrast to common comparative analysis methods that filter sequence homolog data based on alignment score cutoffs, PSAT leverages gene context information for homologs, including those with weak alignment scores, enabling a more sensitive analysis. Features for constraining or ordering results are designed to help researchers browse results from large numbers of comparison genomes in an organized manner. PSAT has been demonstrated to be useful for helping to identify gene orthologs and potential functional gene clusters, and detecting genome modifications that may result in loss of function. CONCLUSION: PSAT allows researchers to investigate the order of genes within local genomic neighborhoods of multiple genomes. A PSAT web server for public use is available for performing analyses on a growing set of reference genomes through any web browser with no client side software setup or installation required. Source code is freely available to researchers interested in setting up a local version of PSAT for analysis of genomes not available through the public server. Access to the public web server and instructions for obtaining source code can be found at http://www.nwrce.org/psat.</protect>
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'''No author listed''' (2008) PSAT: a web tool to compare genomic neighborhoods of multiple prokaryotic genomes. ''BMC Bioinformatics'' '''9''':170
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!align=left  |Abstract
*  [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18366802 PubMed]
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The conservation of gene order among prokaryotic genomes can provide valuable insight into gene function, protein interactions, or events by which genomes have evolved. Although some tools are available for visualizing and comparing the order of genes between genomes of study, few support an efficient and organized analysis between large numbers of genomes. The Prokaryotic Sequence homology Analysis Tool (PSAT) is a web tool for comparing gene neighborhoods among multiple prokaryotic genomes.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18366802 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2358893 PMC2358893]
Online version:[http://dx.doi.org/10.1186/1471-2105-9-170 10.1186/1471-2105-9-170]
Online version:[http://dx.doi.org/10.1186/1471-2105-9-170 10.1186/1471-2105-9-170]
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!align=left  |Keywords
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Algorithms; Base Sequence; Chromosome Mapping/methods; Genome, Archaeal/genetics; Genome, Bacterial/genetics; Internet; Molecular Sequence Data; Sequence Alignment/methods; Sequence Analysis, DNA/methods; Software
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==Significance {{HelpIcon|Help:Literature}} ==
==Significance {{HelpIcon|Help:Literature}} ==
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Revision as of 19:04, 1 September 2013

Citation

No author listed (2008) PSAT: a web tool to compare genomic neighborhoods of multiple prokaryotic genomes. BMC Bioinformatics 9:170

Abstract

The conservation of gene order among prokaryotic genomes can provide valuable insight into gene function, protein interactions, or events by which genomes have evolved. Although some tools are available for visualizing and comparing the order of genes between genomes of study, few support an efficient and organized analysis between large numbers of genomes. The Prokaryotic Sequence homology Analysis Tool (PSAT) is a web tool for comparing gene neighborhoods among multiple prokaryotic genomes.

Links

PubMed PMC2358893 Online version:10.1186/1471-2105-9-170

Keywords

Algorithms; Base Sequence; Chromosome Mapping/methods; Genome, Archaeal/genetics; Genome, Bacterial/genetics; Internet; Molecular Sequence Data; Sequence Alignment/methods; Sequence Analysis, DNA/methods; Software

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Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status
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