PMID:10692383: Difference between revisions

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<span style = 'font-size: large'> '''Rosenberg, EY, Ma, D and Nikaido, H'''  (2000) AcrD of Escherichia coli is an aminoglycoside efflux pump.''J. Bacteriol.'' '''182''':1754-6</span>
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!align=left  |Citation
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'''Rosenberg, EY, Ma, D and Nikaido, H'''  (2000) AcrD of Escherichia coli is an aminoglycoside efflux pump. ''J. Bacteriol.'' '''182''':1754-6
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!align=left  |Abstract
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AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10692383 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC94475 PMC94475]


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|{{TableHeadingColor}} |'''Abstract''' || AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain.
!align=left  |Keywords
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Aminoglycosides; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Carrier Proteins/genetics; Carrier Proteins/metabolism; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/growth & development; Escherichia coli/metabolism; Gene Deletion; Microbial Sensitivity Tests
|{{TableHeadingColor}} nowrap |'''Links''' ||  [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10692383 PubMed]
 
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==Significance {{HelpIcon|Help:Literature}} ==
==Significance {{HelpIcon|Help:Literature}} ==
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==Annotations {{HelpIcon|Help:Literature}}==
==Annotations {{HelpIcon|Help:Literature}}==
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!|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status
 
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==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
==EcoliWiki Links {{HelpIcon|Help:Literature}} ==

Latest revision as of 04:11, 15 September 2013

Citation

Rosenberg, EY, Ma, D and Nikaido, H (2000) AcrD of Escherichia coli is an aminoglycoside efflux pump. J. Bacteriol. 182:1754-6

Abstract

AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain.

Links

PubMed PMC94475

Keywords

Aminoglycosides; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Carrier Proteins/genetics; Carrier Proteins/metabolism; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/growth & development; Escherichia coli/metabolism; Gene Deletion; Microbial Sensitivity Tests

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