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{{Tab On|Quickview|cobB}}{{Tab|Gene|cobB}}{{Tab|Gene Product(s)|cobB}}{{Tab|Expression|cobB}}{{Tab|Evolution|cobB}}{{Tab|On One Page|cobB}}{{TabsBottom}}
{{Tab On|Quickview|cobB}}{{Tab|Gene|cobB}}{{Tab|Gene Product(s)|cobB}}{{Tab|Expression|cobB}}{{Tab|Evolution|cobB}}{{Tab|On One Page|cobB}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[cobB:Gene|''cobB]]'' (synonyms: ''ECK1106, b1120, JW1106, ycfY'')<ref name='LIB:Riley_2006'/>
''cobB''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[cobB:Gene_Product(s)|CobB product]]<ref name='LIB:Riley_2006'/>: deacetylase of acetyl-CoA synthetase, NAD-dependent product, B1120 product, YcfY product
''ECK1106, b1120, JW1106, ycfY''<ref name='LIB:Riley_2006'/>, npdA, ycfY''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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protein deacetylase, Sir2 homolog<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
protein deacetylase, Sir2 homolog<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Sirtuin lysine deacetylase for acetyl-CoA synthetase, NAD-dependent; partial cobalamin biosynthesis pathway present in E. coli<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''deacetylase of acetyl-CoA synthetase, NAD-dependent<ref name='LIB:Riley_2006'/>, B1120<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YcfY<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, CobB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1106, JW1106, npdA, ycfY, b1120''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:ycfX|ycfX]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:ycfX|ycfX]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=cobB&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6577]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120003173&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=cobB&loc=MG1655%3A1178743..1179582,W3110%3A1181097..1181936,DH10B%3A1234188..1235027,REL606%3A1194892..1195731,BW2952%3A1082668..1083507]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1082668&end=1083507&gene=cobB&aa=mlsrrghrlsrfrknkrrlrerlrqriffrdkvvpeamekprvlvltgagisaesgirtfraadglweehrvedvatpegfdrdpelvqafynarrrqlqqpeiqpnaahlalaklqdalgdrfllvtqnidnlheragntnvihmhgellkvrcsqsgqvldwtgdvtpedkchccqfpaplrphvvwfgemplgmdeiymalsmadifiaigtsghvypaagfvheaklhgahtvelnlepsqvgnefaekyygpasqvvpefvekllkglkagsia]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=cobB+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=cobB]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
CobB is primarily characterized in Salmonella (Starai, 2002). CobB may be responsible for additional lysine deacetylations since it is the only sirtuin homolog; Pat may be the general protein acetylase. A large number of lysines are acetylated and deacetylated in E. coli; presumably many or all of them by Pat/CobB (Yu, 2008; Zhang, 2008).<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:55, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

cobB

Gene Synonym(s)

ECK1106, b1120, JW1106, ycfY[1], npdA, ycfY

Product Desc.

protein deacetylase, Sir2 homolog[2][3]

Sirtuin lysine deacetylase for acetyl-CoA synthetase, NAD-dependent; partial cobalamin biosynthesis pathway present in E. coli[4]

Product Synonyms(s)

deacetylase of acetyl-CoA synthetase, NAD-dependent[1], B1120[2][1], YcfY[2][1], CobB[2][1] , ECK1106, JW1106, npdA, ycfY, b1120

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ycfX[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


CobB is primarily characterized in Salmonella (Starai, 2002). CobB may be responsible for additional lysine deacetylations since it is the only sirtuin homolog; Pat may be the general protein acetylase. A large number of lysines are acetylated and deacetylated in E. coli; presumably many or all of them by Pat/CobB (Yu, 2008; Zhang, 2008).[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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