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{{Tab On|Quickview|alkB}}{{Tab|Gene|alkB}}{{Tab|Gene Product(s)|alkB}}{{Tab|Expression|alkB}}{{Tab|Evolution|alkB}}{{Tab|On One Page|alkB}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[alkB:Gene|''alkB]]'' (synonyms: ''ECK2204, b2212, JW2200, aidD'')<ref name='LIB:Riley_2006'/>
''alkB''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[alkB:Gene_Product(s)|AlkB product]]<ref name='LIB:Riley_2006'/>: oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions<ref name='LIB:Riley_2006'/>, B2212<ref name='LIB:EcoCyc10.6'/>, AidD<ref name='LIB:EcoCyc10.6'/>, AlkB<ref name='LIB:EcoCyc10.6'/>
''ECK2204, b2212, JW2200, aidD''<ref name='LIB:Riley_2006'/>, aidD''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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AlkB repair system for alkylated DNA and RNA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
AlkB repair system for alkylated DNA and RNA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


 
Alkylated DNA repair enzyme; alpha-ketoglutarate- and Fe(II)-dependent dioxygenase<ref name='PMID:12226668'/>; releases replication blocks by oxidative demethylation of 1-methyladenine and 3-methylcytosine residues in ssDNA and dsDNA<ref name='PMID:12226667'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions<ref name='LIB:Riley_2006'/>, B2212<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AidD<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AlkB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , aidD, ECK2204, JW2200, b2212''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:ada-alkB|ada-alkB]]<ref name='LIB:EcoCyc10.6'/>, OP00100, [[:Category:txn_units:alkB|alkB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:ada-alkB|ada-alkB]]<ref name='LIB:EcoCyc10.6'/>, OP00100, [[:Category:Txn_unit:alkB|alkB]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=alkB&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10037]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000034&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=alkB&loc=MG1655%3A2307363..2306713,W3110%3A2312675..2312025,REL606%3A2259445..2258795,DH10B%3A2398351..2397701,BW2952%3A2192518..2193168]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2192518&end=2193168&gene=alkB&aa=mldlfadaepwqeplaagavilrrfafnaaeqlirdindvasqspfrqmvtpggytmsvamtncghlgwtthrqgylyspidpqtnkpwpampqsfhnlcqraataagypdfqpdaclinryapgaklslhqdkdepdlrapivsvslglpaifqfgglkrndplkrlllehgdvvvwggesrlfyhgiqplkagfhpltidcrynltfrqagkke]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=alkB+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=alkB]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
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AlkB mutants are extremely sensitive to MMS. Also repairs alkylated mRNA and tRNA in vivo and in vitro, the first example of direct RNA repair. Repairs epsilonA and epsilonC. Ada regulon.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:53, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

alkB

Gene Synonym(s)

ECK2204, b2212, JW2200, aidD[1], aidD

Product Desc.

AlkB repair system for alkylated DNA and RNA[2][3]

Alkylated DNA repair enzyme; alpha-ketoglutarate- and Fe(II)-dependent dioxygenase[4]; releases replication blocks by oxidative demethylation of 1-methyladenine and 3-methylcytosine residues in ssDNA and dsDNA[5]

Product Synonyms(s)

oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions[1], B2212[2][1], AidD[2][1], AlkB[2][1] , aidD, ECK2204, JW2200, b2212

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ada-alkB[2], OP00100, alkB[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


AlkB mutants are extremely sensitive to MMS. Also repairs alkylated mRNA and tRNA in vivo and in vitro, the first example of direct RNA repair. Repairs epsilonA and epsilonC. Ada regulon.[6]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ Falnes, PØ et al. (2002) AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419 178-82 PubMed
  5. ↑ Trewick, SC et al. (2002) Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419 174-8 PubMed
  6. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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