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<noinclude>{{TabsTop}}   
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{{Tab On|Quickview|thiM}}{{Tab|Gene|thiM}}{{Tab|Gene Product(s)|thiM}}{{Tab|Expression|thiM}}{{Tab|Evolution|thiM}}{{Tab|On One Page|thiM}}{{TabsBottom}}
{{Tab On|Quickview|thiM}}{{Tab|Gene|thiM}}{{Tab|Gene Product(s)|thiM}}{{Tab|Expression|thiM}}{{Tab|Evolution|thiM}}{{Tab|On One Page|thiM}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[thiM:Gene|''thiM]]'' (synonyms: ''ECK2097, b2104, JW2091'')<ref name='LIB:Riley_2006'/>
''thiM''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[thiM:Gene_Product(s)|ThiM product]]<ref name='LIB:Riley_2006'/>: hydoxyethylthiazole kinase<ref name='LIB:Riley_2006'/>, B2104<ref name='LIB:EcoCyc10.6'/>, ThiM<ref name='LIB:EcoCyc10.6'/>, 4-methyl-5-(&beta;-hydroxyethyl)thiazole kinase<ref name='LIB:EcoCyc10.6'/>, ATP:4-methyl-5-(2-hydroxyethyl)-thiazole 2-phosphotransferase<ref name='LIB:EcoCyc10.6'/>, THZ kinase<ref name='LIB:EcoCyc10.6'/>
''ECK2097, b2104, JW2091''<ref name='LIB:Riley_2006'/>, JW2091''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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hydroxyethylthiazole kinase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
hydroxyethylthiazole kinase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


 
Hydroxyethylthiazole kinase<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''hydoxyethylthiazole kinase<ref name='LIB:Riley_2006'/>, B2104<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ThiM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, 4-methyl-5-(&beta;-hydroxyethyl)thiazole kinase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ATP:4-methyl-5-(2-hydroxyethyl)-thiazole 2-phosphotransferase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, THZ kinase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK2097, JW2091, b2104''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:thiD|thiD]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:thiD|thiD]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=thiM&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=M007]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120004467&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=thiM&loc=MG1655%3A2183323..2182535,W3110%3A2188635..2187847,REL606%3A2139430..2138642,DH10B%3A2274331..2273543,BW2952%3A2075018..2075806]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2075018&end=2075806&gene=thiM&aa=mqvdllgsaqsahalhlfhqhsplvhcmtndvvqtftantllalgaspamvieteeasqfaaiasallinvgtltqpraqamraaveqakssqtpwtldpvavgaldyrrhfchellsfkpaairgnaseimalagianggrgvdttdaaanaipaaqtlaretgaivvvtgemdyvtdghriigihggdplmtkvvgtgcalsavvaaccalpgdtlenvasachwmkqageravarsegpgsfvphfldalwqltqevqa]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=thiM+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=thiM]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
thiMD operon expression is controlled by a thiamine pyrophosphate (TPP) responsive riboswitch in the 5' UTR. The thiM riboswitch is the target for the antibiotic pyrithiamine. The PDB links are to the structures of various thiM riboswitch/small molecule complexes: 2GDI, TPP; 2HOJ, TPP/Mn2+; 2HOK, TPP/Ca2+; 2HOL, TPP/Ba2+; 2HOM,TMP; 2HOO, BTP; 2HOP, PT (Serganov, 2006; Edwards, 2006).<ref name='LIB:EcoGene'/>
 




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==References==
==References==
{{BacktoTop}}
<references/>
<references/>
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Latest revision as of 21:45, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

thiM

Gene Synonym(s)

ECK2097, b2104, JW2091[1], JW2091

Product Desc.

hydroxyethylthiazole kinase[2][3]

Hydroxyethylthiazole kinase[4]

Product Synonyms(s)

hydoxyethylthiazole kinase[1], B2104[2][1], ThiM[2][1], 4-methyl-5-(β-hydroxyethyl)thiazole kinase[2][1], ATP:4-methyl-5-(2-hydroxyethyl)-thiazole 2-phosphotransferase[2][1], THZ kinase[2][1] , ECK2097, JW2091, b2104

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): thiD[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


thiMD operon expression is controlled by a thiamine pyrophosphate (TPP) responsive riboswitch in the 5' UTR. The thiM riboswitch is the target for the antibiotic pyrithiamine. The PDB links are to the structures of various thiM riboswitch/small molecule complexes: 2GDI, TPP; 2HOJ, TPP/Mn2+; 2HOK, TPP/Ca2+; 2HOL, TPP/Ba2+; 2HOM,TMP; 2HOO, BTP; 2HOP, PT (Serganov, 2006; Edwards, 2006).[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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