cheY:Quickview: Difference between revisions

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{{Tab On|Quickview|cheY}}{{Tab|Gene|cheY}}{{Tab|Gene Product(s)|cheY}}{{Tab|Expression|cheY}}{{Tab|Evolution|cheY}}{{Tab|On One Page|cheY}}{{TabsBottom}}
{{Tab On|Quickview|cheY}}{{Tab|Gene|cheY}}{{Tab|Gene Product(s)|cheY}}{{Tab|Expression|cheY}}{{Tab|Evolution|cheY}}{{Tab|On One Page|cheY}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[cheY:Gene|''cheY]]'' (synonyms: ''ECK1883, b1882, JW1871'')<ref name='LIB:Riley_2006'/>
''cheY''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[cheY:Gene_Product(s)|CheY product, CheY product]]<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>: chemotaxis regulator transmitting signal to flagellar motor component<ref name='LIB:Riley_2006'/>, B1882<ref name='LIB:EcoCyc10.6'/>, CheY<ref name='LIB:EcoCyc10.6'/>, chemotaxis regulator protein CheY-P<SUP>asp</SUP><ref name='LIB:EcoCyc10.6'/>, phosphorylated chemotaxis regulator protein CheY<ref name='LIB:EcoCyc10.6'/>, modified chemotaxis regulator protein CheY<ref name='LIB:EcoCyc10.6'/>, phospho-CheY<ref name='LIB:EcoCyc10.6'/>, chemotaxis regulator protein CheY<ref name='LIB:EcoCyc10.6'/>, chemotaxis response regulator protein CheY<ref name='LIB:EcoCyc10.6'/>, unmodified chemotaxis protein CheY<ref name='LIB:EcoCyc10.6'/>
''ECK1883, b1882, JW1871''<ref name='LIB:Riley_2006'/>, JW1871''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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CheY<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
chemotaxis regulator transmitting signal to flagellar motor component<ref name='LIB:Riley_2006'/>
 


Response regulator for chemotactic signal transduction; CheA is the cognate sensor protein<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''B1882<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ECK1883, JW1871, b1882''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:tar-tap-cheRBYZ|tar-tap-cheRBYZ]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:tar-tap-cheRBYZ|tar-tap-cheRBYZ]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=cheY&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10150]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000146&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=cheY&loc=MG1655%3A1965461..1965072,W3110%3A1969151..1968762,DH10B%3A2056032..2055643,REL606%3A1946207..1945818,BW2952%3A1857131..1857520]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1857131&end=1857520&gene=cheY&aa=madkelkflvvddfstmrrivrnllkelgfnnveeaedgvdalnklqaggygfvisdwnmpnmdglellktiradgamsalpvlmvtaeakkeniiaaaqagasgyvvkpftaatleeklnkifeklgm]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=cheY+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=cheY]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
CheY is acetylated at lysine residues 92 and 109 by acetyl-CoA synthase (Acs). Proposed mechanism for optimum chemotaxis suggests alteration of side chain signaling state by rotation of Tyr106 side chain; this is presumably modulated by phosphorylation state of the molecule. A mutation resulting in a tyrosine to tryptophan substitution at position 106 results in a hyperactive phenotype, while a double mutation T87I/Y106W resulted in loss of activity. Substitutions at ILE95 affect FliM binding. Flagellar regulon.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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<references/>
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Latest revision as of 21:52, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

cheY

Gene Synonym(s)

ECK1883, b1882, JW1871[1], JW1871

Product Desc.

chemotaxis regulator transmitting signal to flagellar motor component[1]

Response regulator for chemotactic signal transduction; CheA is the cognate sensor protein[2]

Product Synonyms(s)

B1882[3][1], ECK1883, JW1871, b1882

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): tar-tap-cheRBYZ[3]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


CheY is acetylated at lysine residues 92 and 109 by acetyl-CoA synthase (Acs). Proposed mechanism for optimum chemotaxis suggests alteration of side chain signaling state by rotation of Tyr106 side chain; this is presumably modulated by phosphorylation state of the molecule. A mutation resulting in a tyrosine to tryptophan substitution at position 106 results in a hyperactive phenotype, while a double mutation T87I/Y106W resulted in loss of activity. Substitutions at ILE95 affect FliM binding. Flagellar regulon.[2]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  3. ↑ 3.0 3.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
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