leuO:Quickview: Difference between revisions

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{|   id="M49aeeafe83015" class=" tableEdit New_Quickview_Table"


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!align=left {{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[leuO:Gene|''leuO]]'' (synonyms: ''ECK0078, b0076, JW0075'')<ref name='LIB:Riley_2006'/>
''leuO''
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!align=left {{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[leuO:Gene_Product(s)|LeuO product]]<ref name='LIB:Riley_2006'/>: DNA-binding transcriptional activator product, B0076 product, affects expression of small regulatory Dsr-RNA, translational regulation of rpoS, relieves bgl silencing product
''ECK0078, b0076, JW0075''<ref name='LIB:Riley_2006'/>, JW0075''
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!align=left {{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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LeuO transcriptional activator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
LeuO transcriptional activator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Pleiotropic transcriptional regulator; regulates dsrA; relieves bgl silencing, multi-copy represses cadC<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Product Synonyms(s)
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''DNA-binding transcriptional activator<ref name='LIB:Riley_2006'/>, B0076<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, LeuO<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, affects expression of small regulatory Dsr-RNA<ref name='PMID:9302018' />, translational regulation of rpoS, relieves bgl silencing<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0078, JW0075, b0076''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:leuO|leuO]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:leuO|leuO]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=leuO&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10531]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000524&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=leuO&loc=MG1655%3A84368..85312,W3110%3A84368..85312,REL606%3A87172..88116,BW2952%3A84367..85311]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=84367&end=85311&gene=leuO&aa=mthstamdsvfirtrifmfsefysfcfflfymhdksyssglflcipirerelsvtvelsmpevqtdhpetaelskpqlrmvdlnlltvfdavmqeqnitraahvlgmsqpavsnavarlkvmfndelfvrygrgiqptarafqlfgsvrqalqlvqnelpgsgfepasservfhlcvcspldsiltsqiynhieqiapnihvmfksslnqntehqlryqetefvisyedfhrpeftsvplfkdemvlvasknhptikgpllkhdvyneqhaavsldrfasfsqpwydtvdkqasiayqgmammsvlsvvsqthlvaiaprwlaeefaeslelqvlplplkqnsrtcylswheaagrdkghqwmeeqlvsickr]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=leuO+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=leuO]]&nbsp;&nbsp;


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Latest revision as of 21:48, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

leuO

Gene Synonym(s)

ECK0078, b0076, JW0075[1], JW0075

Product Desc.

LeuO transcriptional activator[2][3]

Pleiotropic transcriptional regulator; regulates dsrA; relieves bgl silencing, multi-copy represses cadC[4]

Product Synonyms(s)

DNA-binding transcriptional activator[1], B0076[2][1], LeuO[2][1], affects expression of small regulatory Dsr-RNA[5], translational regulation of rpoS, relieves bgl silencing[2][1] , ECK0078, JW0075, b0076

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): leuO[2]

Regulation/Activity
Quick Links



        

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Notes

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LysR-family. leuO is upstream and divergent of the leuABCD operon. LeuO is required for recovery of a relA1 strain from starvation for brached-chain amino acids. In Salmonella, LeuO relieves leuABCD silencing mediated by an AT-rich silencer sequence between leuO and leuA. In Salmonella, LeuO expression is activated by an ilvHI-leuO-leuA promoter relay mechanism mediated by DNA supercoiling, possibly explaining the ppGpp-dependent increase in E. coli LeuO expression in stationary phase as an indirect effect of ppGpp stimulating the expression of Lrp, an ilvHI activator.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Klauck, E et al. (1997) The LysR-like regulator LeuO in Escherichia coli is involved in the translational regulation of rpoS by affecting the expression of the small regulatory DsrA-RNA. Mol. Microbiol. 25 559-69 PubMed
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