PMID:2139647: Difference between revisions

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<span style = 'font-size: large'> '''Chen, KS, Peters, TC and Walker, JR'''  (1990) A minor arginine tRNA mutant limits translation preferentially of a protein dependent on the cognate codon.''J. Bacteriol.'' '''172''':2504-10</span>
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'''Chen, KS, Peters, TC and Walker, JR'''  (1990) A minor arginine tRNA mutant limits translation preferentially of a protein dependent on the cognate codon. ''J. Bacteriol.'' '''172''':2504-10
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!align=left  |Abstract
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The Escherichia coli argU gene encodes a rare arginine tRNA (anticodon UCU) that translates the similarly rare AGA codon. The argU10(Ts) mutation is a transition that changes the first nucleotide of the mature tRNA from G to A, presumably destabilizing the acceptor stem. This mutation, when present in haploid condition in the chromosome, reduces the growth rate at 30 degrees C and results in cessation of growth after 60 to 90 min at 43 degrees C. The mutation also preferentially limits (compared with total protein synthesis) translation of an induced gene that depends on five AGA codons, i.e., the lambda cI repressor gene. Translation of another inducible protein, beta-galactosidase, which does not involve AGA codons, was inhibited to a much lesser extent. The chromosomal argU(Ts) mutation also confers the Pin phenotype, that is, loss of ability of the host, as a P2 lysogen, to inhibit growth of bacteriophage lambda, probably the result of reduced translation of the P2 old gene, which contains five AGA codons (E. Haggård-Ljungquist, V. Barreiro, R. Calendar, D. M. Kurnit, and H. Cheng, Gene 85:25-33, 1989).
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2139647 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC208890 PMC208890]


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|{{TableHeadingColor}} |'''Abstract''' || The Escherichia coli argU gene encodes a rare arginine tRNA (anticodon UCU) that translates the similarly rare AGA codon. The argU10(Ts) mutation is a transition that changes the first nucleotide of the mature tRNA from G to A, presumably destabilizing the acceptor stem. This mutation, when present in haploid condition in the chromosome, reduces the growth rate at 30 degrees C and results in cessation of growth after 60 to 90 min at 43 degrees C. The mutation also preferentially limits (compared with total protein synthesis) translation of an induced gene that depends on five AGA codons, i.e., the lambda cI repressor gene. Translation of another inducible protein, beta-galactosidase, which does not involve AGA codons, was inhibited to a much lesser extent. The chromosomal argU(Ts) mutation also confers the Pin phenotype, that is, loss of ability of the host, as a P2 lysogen, to inhibit growth of bacteriophage lambda, probably the result of reduced translation of the P2 old gene, which contains five AGA codons (E. Haggård-Ljungquist, V. Barreiro, R. Calendar, D. M. Kurnit, and H. Cheng, Gene 85:25-33, 1989).
!align=left  |Keywords
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Alleles; Anticodon/genetics; Bacteriophage lambda/genetics; Base Sequence; Chromosome Mapping; Chromosomes, Bacterial; Cloning, Molecular; Codon/genetics; DNA, Bacterial/genetics; DNA, Bacterial/isolation & purification; DNA, Recombinant/metabolism; Escherichia coli/genetics; Escherichia coli/growth & development; Genes, Bacterial; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Protein Biosynthesis; RNA, Transfer, Amino Acid-Specific/genetics; RNA, Transfer, Arg/genetics; beta-Galactosidase/genetics; beta-Galactosidase/metabolism
|{{TableHeadingColor}} nowrap |'''Links''' ||  [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2139647 PubMed]
 
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==Significance {{HelpIcon|Help:Literature}} ==
==Significance {{HelpIcon|Help:Literature}} ==
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==Annotations {{HelpIcon|Help:Literature}}==
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==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
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Latest revision as of 04:38, 15 September 2013

Citation

Chen, KS, Peters, TC and Walker, JR (1990) A minor arginine tRNA mutant limits translation preferentially of a protein dependent on the cognate codon. J. Bacteriol. 172:2504-10

Abstract

The Escherichia coli argU gene encodes a rare arginine tRNA (anticodon UCU) that translates the similarly rare AGA codon. The argU10(Ts) mutation is a transition that changes the first nucleotide of the mature tRNA from G to A, presumably destabilizing the acceptor stem. This mutation, when present in haploid condition in the chromosome, reduces the growth rate at 30 degrees C and results in cessation of growth after 60 to 90 min at 43 degrees C. The mutation also preferentially limits (compared with total protein synthesis) translation of an induced gene that depends on five AGA codons, i.e., the lambda cI repressor gene. Translation of another inducible protein, beta-galactosidase, which does not involve AGA codons, was inhibited to a much lesser extent. The chromosomal argU(Ts) mutation also confers the Pin phenotype, that is, loss of ability of the host, as a P2 lysogen, to inhibit growth of bacteriophage lambda, probably the result of reduced translation of the P2 old gene, which contains five AGA codons (E. Haggård-Ljungquist, V. Barreiro, R. Calendar, D. M. Kurnit, and H. Cheng, Gene 85:25-33, 1989).

Links

PubMed PMC208890

Keywords

Alleles; Anticodon/genetics; Bacteriophage lambda/genetics; Base Sequence; Chromosome Mapping; Chromosomes, Bacterial; Cloning, Molecular; Codon/genetics; DNA, Bacterial/genetics; DNA, Bacterial/isolation & purification; DNA, Recombinant/metabolism; Escherichia coli/genetics; Escherichia coli/growth & development; Genes, Bacterial; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Protein Biosynthesis; RNA, Transfer, Amino Acid-Specific/genetics; RNA, Transfer, Arg/genetics; beta-Galactosidase/genetics; beta-Galactosidase/metabolism

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