PMID:10972793: Difference between revisions
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!align=left |Citation | |||
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'''Norris, V, Fralick, J and Danchin, A''' (2000) A SeqA hyperstructure and its interactions direct the replication and sequestration of DNA. ''Mol. Microbiol.'' '''37''':696-702 | |||
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!align=left |Abstract | |||
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A level of explanation in biology intermediate between macromolecules and cells has recently been proposed. This level is that of hyperstructures. One class of hyperstructures comprises the genes, mRNA, proteins and lipids that assemble to fulfil a particular function and disassemble when no longer required. To reason in terms of hyperstructures, it is essential to understand the factors responsible for their formation. These include the local concentration of sites on DNA and their cognate DNA-binding proteins. In Escherichia coli, the formation of a SeqA hyperstructure via the phenomenon of local concentration may explain how the binding of SeqA to hemimethylated GATC sequences leads to the sequestration of newly replicated origins of replication. | |||
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10972793 PubMed] | |||
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| | !align=left |Keywords | ||
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|- | Bacterial Outer Membrane Proteins; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Bacterial Proteins/physiology; DNA/metabolism; DNA Replication/physiology; DNA-Binding Proteins; Escherichia coli Proteins; Protein Conformation; Transcription Factors | ||
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==Significance {{HelpIcon|Help:Literature}} == | ==Significance {{HelpIcon|Help:Literature}} == | ||
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==Annotations {{HelpIcon|Help:Literature}}== | ==Annotations {{HelpIcon|Help:Literature}}== | ||
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==EcoliWiki Links {{HelpIcon|Help:Literature}} == | ==EcoliWiki Links {{HelpIcon|Help:Literature}} == | ||
Latest revision as of 04:13, 15 September 2013
| Citation |
Norris, V, Fralick, J and Danchin, A (2000) A SeqA hyperstructure and its interactions direct the replication and sequestration of DNA. Mol. Microbiol. 37:696-702 |
|---|---|
| Abstract |
A level of explanation in biology intermediate between macromolecules and cells has recently been proposed. This level is that of hyperstructures. One class of hyperstructures comprises the genes, mRNA, proteins and lipids that assemble to fulfil a particular function and disassemble when no longer required. To reason in terms of hyperstructures, it is essential to understand the factors responsible for their formation. These include the local concentration of sites on DNA and their cognate DNA-binding proteins. In Escherichia coli, the formation of a SeqA hyperstructure via the phenomenon of local concentration may explain how the binding of SeqA to hemimethylated GATC sequences leads to the sequestration of newly replicated origins of replication. |
| Links | |
| Keywords |
Bacterial Outer Membrane Proteins; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Bacterial Proteins/physiology; DNA/metabolism; DNA Replication/physiology; DNA-Binding Proteins; Escherichia coli Proteins; Protein Conformation; Transcription Factors |
| edit table |
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