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{{Tab On|Quickview|mdtC}}{{Tab|Gene|mdtC}}{{Tab|Gene Product(s)|mdtC}}{{Tab|Expression|mdtC}}{{Tab|Evolution|mdtC}}{{Tab|On One Page|mdtC}}{{TabsBottom}}
{{Tab On|Quickview|mdtC}}{{Tab|Gene|mdtC}}{{Tab|Gene Product(s)|mdtC}}{{Tab|Expression|mdtC}}{{Tab|Evolution|mdtC}}{{Tab|On One Page|mdtC}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[mdtC:Gene|''mdtC]]'' (synonyms: ''ECK2072, b2076, JW2061, yegO'')<ref name='LIB:Riley_2006'/>
''mdtC''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[mdtC:Gene_Product(s)|MdtC product]]<ref name='LIB:Riley_2006'/>: multidrug efflux system, subunit C<ref name='LIB:Riley_2006'/>, B2076<ref name='LIB:EcoCyc10.6'/>, MdtC<ref name='LIB:EcoCyc10.6'/>, YegO<ref name='LIB:EcoCyc10.6'/>, [[:Category:Complex:MdtABC RND-type Drug Exporter|MdtABC RND-type Drug Exporter]]<ref name='LIB:EcoCyc10.6'/>
''ECK2072, b2076, JW2061, yegO''<ref name='LIB:Riley_2006'/>, yegO''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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MdtC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
MdtC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:MdtABC RND-type Drug Exporter|MdtABC RND-type Drug Exporter]]<ref name='LIB:EcoCyc10.6'/>; [[:Category:Complex:MdtABC RND-type Drug Exporter|MdtABC-TolC Multidrug Efflux Transport System]]<ref name='LIB:EcoCyc11.1'/>


MdtABC-TolC efflux pump, multidrug resistance; heterodimeric RND-type transporter<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''multidrug efflux system, subunit C<ref name='LIB:Riley_2006'/>, B2076<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MdtC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YegO<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK2072, JW2061, yegO, b2076''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:mdtABCD-baeSR|mdtABCD-baeSR]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:mdtABCD-baeSR|mdtABCD-baeSR]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=mdtC&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G7115]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120003701&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=mdtC&loc=MG1655%3A2156410..2159487,W3110%3A2160523..2163600,DH10B%3A2247418..2250495,REL606%3A2091494..2094571,BW2952%3A2048893..2051970]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2048893&end=2051970&gene=mdtC&aa=mkffalfiyrpvatillsvaitlcgilgfrmlpvaplpqvdfpviivsaslpgaspetmassvatplerslgriagvsemtsssslgstriilqfdfdrdingaardvqaainaaqsllpsgmpsrptyrkanpsdapimiltltsdtysqgelydfastqlaptisqidgvgdvdvggsslpavrvglnpqalfnqgvslddvrtavsnanvrkpqgaledgthrwqiqtndelktaaeyqpliihynnggavrlgdvatvtdsvqdvrnagmtnakpaillmirklpeaniiqtvdsiraklpelqetipaaidlqiaqdrsptirasleeveqtliisvalvilvvflflrsgratiipavsvpvsligtfaamylcgfslnnlslmaltiatgfvvddaivvleniarhleagmkplqaalqgtrevgftvlsmslslvavflplllmgglpgrllrefavtlsvaigisllvsltltpmmcgwmlkaskpreqkrlrgfgrmlvalqqgygkslkwvlnhtrlvgvvllgtialniwlyisipktffpeqdtgvlmggiqadqsisfqamrgklqdfmkiirddpavdnvtgftggsrvnsgmmfitlkprdersetaqqiidrlrvklakepganlflmavqdirvggrqsnasyqytllsddlaalrewepkirkklatlpeladvnsdqqdngaemnlvydrdtmarlgidvqaansllnnafgqrqistiyqpmnqykvvmevdprytqdisalekmfvinnegkaiplsyfakwqpanaplsvnhqglsaastisfnlptgkslsdasaaidramtqlgvpstvrgsfagtaqvfqetmnsqviliiaaiatvyivlgilyesyvhpltilstlpsagvgallalelfnapfslialigimlligivkknaimmvdfaleaqrhgnltpqeaifqacllrfrpimmttlaalfgalplvlsggdgselrqplgitivgglvmsqlltlyttpvvylffdrlrlrfsrkpkqtvte]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=mdtC+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=mdtC]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
mdtABC overexpression confers resistance to deoxycholate and novobiocin.  An mdtABC mutant is not sensitive to deoxycholate and Nov. Upregulated by GSNO in defined medium (aerobic). BaeSR, EvgAS regulons.<ref name='LIB:EcoGene'/>
 




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==References==
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Latest revision as of 21:48, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

mdtC

Gene Synonym(s)

ECK2072, b2076, JW2061, yegO[1], yegO

Product Desc.

MdtC[2][3];

Component of MdtABC RND-type Drug Exporter[2]; MdtABC-TolC Multidrug Efflux Transport System[3]

MdtABC-TolC efflux pump, multidrug resistance; heterodimeric RND-type transporter[4]

Product Synonyms(s)

multidrug efflux system, subunit C[1], B2076[2][1], MdtC[2][1], YegO[2][1] , ECK2072, JW2061, yegO, b2076

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): mdtABCD-baeSR[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


mdtABC overexpression confers resistance to deoxycholate and novobiocin. An mdtABC mutant is not sensitive to deoxycholate and Nov. Upregulated by GSNO in defined medium (aerobic). BaeSR, EvgAS regulons.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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