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{{Tab On|Quickview|htpX}}{{Tab|Gene|htpX}}{{Tab|Gene Product(s)|htpX}}{{Tab|Expression|htpX}}{{Tab|Evolution|htpX}}{{Tab|On One Page|htpX}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[htpX:Gene|''htpX]]'' (synonyms: ''ECK1828, b1829, JW1818'')<ref name='LIB:Riley_2006'/>
''htpX''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[htpX:Gene_Product(s)|HtpX product]]<ref name='LIB:Riley_2006'/>: predicted endopeptidase<ref name='LIB:Riley_2006'/>, B1829<ref name='LIB:EcoCyc10.6'/>, HtpX<ref name='LIB:EcoCyc10.6'/>
''ECK1828, b1829, JW1818''<ref name='LIB:Riley_2006'/>, JW1818''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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heat shock protein, integral membrane protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
heat shock protein, integral membrane protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


 
Zinc metalloprotease HtpX, membrane-bound; cleaves SecY in vivo and in vitro; self-cleaves; M48 family<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''predicted endopeptidase<ref name='LIB:Riley_2006'/>, B1829<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HtpX<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1828, JW1818, b1829''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:htpX|htpX]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:htpX|htpX]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=htpX&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10462]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000455&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=htpX&loc=MG1655%3A1910600..1909719,W3110%3A1914290..1913409,DH10B%3A2001171..2000290,REL606%3A1891153..1890272,BW2952%3A1801778..1802659]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1801778&end=1802659&gene=htpX&aa=mmrialflltnlavmvvfglvlsltgiqsssvqglmimallfgfggsfvsllmskwmalrsvggevieqprnererwlvntvatqarqagiampqvaiyhapdinafatgarrdaslvavstgllqnmspdeaeaviaheishiangdmvtmtliqgvvntfvifisrilaqlaagfmggnrdegeesngnpliyfavatvlelvfgilasiitmwfsrhrefhadagsaklvgrekmiaalqrlktsyepqeatsmmalcingkskslselfmthppldkriealrtgeylk]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=htpX+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=htpX]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
Overexpression of truncated HtpX promotes degradation of incomplete proteins in puromycin-treated cells.  HtpX collaborates with FtsH to eliminate abnormal membrane proteins: an hflX ftsH double mutant is temperature-sensitive for growth.  Inactivation of putative protease active site residues abolishes ability to cross-complement defects in the FtsH protease.  Start codon verified by toeprint analysis (Kornitzer, 1991).  HtpX has a cytosolic active site.  HtpX in vivo cleavage of SecY is seen when both are overproduced.  Cpx regulon.  RpoH regulon.  Synthetic lethal with hflB(ftsH) in fabZ(SfhC) background. HtpX has two TM helices. htpX, yggG, yfgC and ycaL are paralogs.<ref name='LIB:EcoGene'/>
 




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==References==
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Latest revision as of 21:49, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

htpX

Gene Synonym(s)

ECK1828, b1829, JW1818[1], JW1818

Product Desc.

heat shock protein, integral membrane protein[2][3]

Zinc metalloprotease HtpX, membrane-bound; cleaves SecY in vivo and in vitro; self-cleaves; M48 family[4]

Product Synonyms(s)

predicted endopeptidase[1], B1829[2][1], HtpX[2][1] , ECK1828, JW1818, b1829

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): htpX[2]

Regulation/Activity
Quick Links



        

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Notes

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Overexpression of truncated HtpX promotes degradation of incomplete proteins in puromycin-treated cells. HtpX collaborates with FtsH to eliminate abnormal membrane proteins: an hflX ftsH double mutant is temperature-sensitive for growth. Inactivation of putative protease active site residues abolishes ability to cross-complement defects in the FtsH protease. Start codon verified by toeprint analysis (Kornitzer, 1991). HtpX has a cytosolic active site. HtpX in vivo cleavage of SecY is seen when both are overproduced. Cpx regulon. RpoH regulon. Synthetic lethal with hflB(ftsH) in fabZ(SfhC) background. HtpX has two TM helices. htpX, yggG, yfgC and ycaL are paralogs.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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