PMID:372184: Difference between revisions

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<span style = 'font-size: large'> '''Stayton, MM and Fromm, HJ'''  (1979) Guanosine 5'-diphosphate-3'-diphosphate inhibition of adenylosuccinate synthetase.''J. Biol. Chem.'' '''254''':2579-81</span>
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!align=left  |Citation
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'''Stayton, MM and Fromm, HJ'''  (1979) Guanosine 5'-diphosphate-3'-diphosphate inhibition of adenylosuccinate synthetase. ''J. Biol. Chem.'' '''254''':2579-81
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!align=left  |Abstract
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The mechanism of ppGpp inhibition of adenylosuccinate synthetase (EC 6.3.4.4) was examined. Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP. This is in contrast to an earlier report (Gallant, J., Irr, J., and Cashel, M. (1971) J. Biol. Chem. 246, 5812-5816), which suggested that ppGpp did not bind at the GTP site. Possible reasons for the discrepancy are discussed. The potency of the ppGpp inhibition is confirmed.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=372184 PubMed]


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|{{TableHeadingColor}} |'''Abstract''' || The mechanism of ppGpp inhibition of adenylosuccinate synthetase (EC 6.3.4.4) was examined. Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP. This is in contrast to an earlier report (Gallant, J., Irr, J., and Cashel, M. (1971) J. Biol. Chem. 246, 5812-5816), which suggested that ppGpp did not bind at the GTP site. Possible reasons for the discrepancy are discussed. The potency of the ppGpp inhibition is confirmed.
!align=left  |Keywords
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Adenylosuccinate Synthase/antagonists & inhibitors; Escherichia coli/enzymology; Guanine Nucleotides/pharmacology; Guanosine Tetraphosphate/pharmacology; Guanosine Triphosphate/pharmacology; Inosine Monophosphate/pharmacology; Kinetics; Ligases/antagonists & inhibitors
|{{TableHeadingColor}} nowrap |'''Links''' ||  [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=372184 PubMed]
 
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Latest revision as of 04:47, 15 September 2013

Citation

Stayton, MM and Fromm, HJ (1979) Guanosine 5'-diphosphate-3'-diphosphate inhibition of adenylosuccinate synthetase. J. Biol. Chem. 254:2579-81

Abstract

The mechanism of ppGpp inhibition of adenylosuccinate synthetase (EC 6.3.4.4) was examined. Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP. This is in contrast to an earlier report (Gallant, J., Irr, J., and Cashel, M. (1971) J. Biol. Chem. 246, 5812-5816), which suggested that ppGpp did not bind at the GTP site. Possible reasons for the discrepancy are discussed. The potency of the ppGpp inhibition is confirmed.

Links

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Keywords

Adenylosuccinate Synthase/antagonists & inhibitors; Escherichia coli/enzymology; Guanine Nucleotides/pharmacology; Guanosine Tetraphosphate/pharmacology; Guanosine Triphosphate/pharmacology; Inosine Monophosphate/pharmacology; Kinetics; Ligases/antagonists & inhibitors

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