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<span style = 'font-size: large'> '''Dame, RT and Goosen, N'''  (2002) HU: promoting or counteracting DNA compaction?''FEBS Lett.'' '''529''':151-6</span>
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!align=left  |Citation
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'''Dame, RT and Goosen, N'''  (2002) HU: promoting or counteracting DNA compaction? ''FEBS Lett.'' '''529''':151-6
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!align=left  |Abstract
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The role of HU in Escherichia coli as both a protein involved in DNA compaction and as a protein with regulatory function seems to be firmly established. However, a critical look at the available data reveals that this is not true for each of the proposed roles of this protein. The role of HU as a regulatory or accessory protein in a number of systems has been thoroughly investigated and in many cases has been largely elucidated. However, almost 30 years after its discovery, convincing evidence for the proposed role of HU in DNA compaction is still lacking. Here we present an extensive literature survey of the available data which, in combination with novel microscopic insights, suggests that the role of HU could be the opposite as well. The protein is likely to play an architectural role, but instead of being responsible for DNA compaction it could be involved in antagonising compaction by other proteins such as H-NS.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12372591 PubMed]


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|{{TableHeadingColor}} |'''Abstract''' || The role of HU in Escherichia coli as both a protein involved in DNA compaction and as a protein with regulatory function seems to be firmly established. However, a critical look at the available data reveals that this is not true for each of the proposed roles of this protein. The role of HU as a regulatory or accessory protein in a number of systems has been thoroughly investigated and in many cases has been largely elucidated. However, almost 30 years after its discovery, convincing evidence for the proposed role of HU in DNA compaction is still lacking. Here we present an extensive literature survey of the available data which, in combination with novel microscopic insights, suggests that the role of HU could be the opposite as well. The protein is likely to play an architectural role, but instead of being responsible for DNA compaction it could be involved in antagonising compaction by other proteins such as H-NS.
!align=left  |Keywords
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Bacterial Proteins/physiology; DNA, Bacterial/chemistry; DNA, Bacterial/metabolism; DNA-Binding Proteins/physiology; Escherichia coli/genetics; Escherichia coli/metabolism; Nucleic Acid Conformation
|{{TableHeadingColor}} nowrap |'''Links''' ||  [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12372591 PubMed]
 
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==Annotations {{HelpIcon|Help:Literature}}==
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Latest revision as of 04:18, 15 September 2013

Citation

Dame, RT and Goosen, N (2002) HU: promoting or counteracting DNA compaction? FEBS Lett. 529:151-6

Abstract

The role of HU in Escherichia coli as both a protein involved in DNA compaction and as a protein with regulatory function seems to be firmly established. However, a critical look at the available data reveals that this is not true for each of the proposed roles of this protein. The role of HU as a regulatory or accessory protein in a number of systems has been thoroughly investigated and in many cases has been largely elucidated. However, almost 30 years after its discovery, convincing evidence for the proposed role of HU in DNA compaction is still lacking. Here we present an extensive literature survey of the available data which, in combination with novel microscopic insights, suggests that the role of HU could be the opposite as well. The protein is likely to play an architectural role, but instead of being responsible for DNA compaction it could be involved in antagonising compaction by other proteins such as H-NS.

Links

PubMed

Keywords

Bacterial Proteins/physiology; DNA, Bacterial/chemistry; DNA, Bacterial/metabolism; DNA-Binding Proteins/physiology; Escherichia coli/genetics; Escherichia coli/metabolism; Nucleic Acid Conformation

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