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{|   id="P49aee92be4f1c"  class=" tableEdit New_Quickview_Table" 
 
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[hsdS:Gene|''hsdS]]'' (synonyms: ''ECK4338, b4348, JW4311, hss, hsp, rm'')<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
''hsdS''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[hsdS:Gene_Product(s)|HsdS product]]<ref name='LIB:Riley_2006'/>: specificity determinant for hsdM and hsdR product, B4348 product, Hss product, Hsp product
''ECK4338, b4348, JW4311, hss, hsp, rm''<ref name='LIB:Riley_2006'/><ref name='LIB:EcoCyc10.6'/>
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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specificity determinant for hsdM and hsdR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
specificity determinant for hsdM and hsdR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:<I>Eco</I>KI restriction-modification system|<I>Eco</I>KI restriction-modification system]]<ref name='LIB:EcoCyc11.1'/>
Component of [[:Category:Complex:<I>Eco</I>KI restriction-modification system|<I>Eco</I>KI restriction-modification system]]<ref name='LIB:EcoCyc11.1'/>


Specificity determinant for HsdM and HsdR<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''specificity determinant for hsdM and hsdR<ref name='LIB:Riley_2006'/>, B4348<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hss<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Hsp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HsdS<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK4338, hsp, hss, JW4311, b4348''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:hsdMS|hsdMS]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:hsdMS|hsdMS]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=hsdS&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10460]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000453&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=hsdS&loc=MG1655%3A4579485..4578091,W3110%3A4586142..4584748,REL606%3A4559437..4558013,BW2952%3A4516575..4517969]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=4516575&end=4517969&gene=hsdS&aa=msagklpegwviapvstvttlirgvtykkeqainylkddylpliranniqngkfdttdlvfvpknlvkesqkispediviamssgsksvvgksahqhlpfecsfgafcgvlrpeklifsgfiahftksslyrnkisslsaganinnikpasfdlinipipplaeqkiiaekldtllaqvdstkarfeqipqilkrfrqavlggavngkltekwrnfepqhsvfkklnfesiltelrnglsskpnesgvghpilrissvraghvdqndirflecseselnrhklqdgdllftryngslefvgvcgllkklqhqnllypdklirarltkdalpeyieiffsspsarnammncvkttsgqkgisgkdiksqvvllppvkeqaeivrrveqlfayadtiekqvnnalarvnnltqsilakafrgeltaqwraenpdlisgensaaallekikaeraasggkkasrkks]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=hsdS+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=hsdS]]&nbsp;&nbsp;
 
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Substitution of Trp212 to Arg alters the protein-protein interaction with HsdM, in turn effecting the DNA binding of the molecule; DNA binding in the mutant is restored by HsdR binding.<ref name='LIB:EcoGene'/>




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==References==
==References==
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Latest revision as of 21:49, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

hsdS

Gene Synonym(s)

ECK4338, b4348, JW4311, hss, hsp, rm[1][2]

Product Desc.

specificity determinant for hsdM and hsdR[2][3];

Component of [[:Category:Complex:EcoKI restriction-modification system|EcoKI restriction-modification system]][3]

Specificity determinant for HsdM and HsdR[4]

Product Synonyms(s)

specificity determinant for hsdM and hsdR[1], B4348[2][1], Hss[2][1], Hsp[2][1], HsdS[2][1] , ECK4338, hsp, hss, JW4311, b4348

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): hsdMS[2]

Regulation/Activity
Quick Links



        

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Notes

The restriction-modification complex EcoKI is comprised of three polypeptide subunits coded for by the genes hsdS, hsdM, and hsdR. HsdS is the polypeptide that directly interacts with DNA through the use of two target recognition domain (TRD) sequences first isolated by Fuller-Pace and Murray.[5] HsdS recognizes and binds to the nucleotide sequence 5' AAC(N)6GTGC. Fuller-Pace and Murray determined this sequence of the TRDs in hsdS after recombining two homologous hsdS genes from a family of restriction-modification complexes.

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Substitution of Trp212 to Arg alters the protein-protein interaction with HsdM, in turn effecting the DNA binding of the molecule; DNA binding in the mutant is restored by HsdR binding.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Fuller-Pace, FV & Murray, NE (1986) Two DNA recognition domains of the specificity polypeptides of a family of type I restriction enzymes. Proc. Natl. Acad. Sci. U.S.A. 83 9368-72 PubMed
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