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{{Tab On|Quickview|yjjG}}{{Tab|Gene|yjjG}}{{Tab|Gene Product(s)|yjjG}}{{Tab|Expression|yjjG}}{{Tab|Evolution|yjjG}}{{Tab|On One Page|yjjG}}{{TabsBottom}}
{{Tab On|Quickview|yjjG}}{{Tab|Gene|yjjG}}{{Tab|Gene Product(s)|yjjG}}{{Tab|Expression|yjjG}}{{Tab|Evolution|yjjG}}{{Tab|On One Page|yjjG}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[yjjG:Gene|''yjjG]]'' (synonyms: ''ECK4365, b4374, JW4336'')<ref name='LIB:Riley_2006'/>
''yjjG''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[yjjG:Gene_Product(s)|YjjG product]]<ref name='LIB:Riley_2006'/>: predicted hydrolase<ref name='LIB:Riley_2006'/>, B4374<ref name='LIB:EcoCyc10.6'/>, YjjG<ref name='LIB:EcoCyc10.6'/>
''ECK4365, b4374, JW4336''<ref name='LIB:Riley_2006'/>, JW4336''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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pyrimidine nucleotidase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
pyrimidine nucleotidase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


 
Noncanonical pyrimidine nucleotide house-cleaning phosphatase; dUMP phosphatase activity<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''predicted hydrolase <ref name='LIB:Riley_2006'/>, B4374 <ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YjjG <ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK4365, JW4336, b4374''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:holD|holD]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:holD|holD]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=yjjG&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG12115]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120002019&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=yjjG&loc=MG1655%3A4606669..4607346,W3110%3A4613326..4614003,DH10B%3A4653131..4653808,REL606%3A4597880..4598557,BW2952%3A4545153..4545830]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=4545153&end=4545830&gene=yjjG&aa=mkwdwiffdadetlftfdsftglqrmfldysvtftaedfqdyqavnkplwvdyqngaitslqlqhgrfeswaerlnvepgklneafinamaeictplpgavsllnairgnakigiitngfsalqqvrlertglrdyfdllviseevgvakpnkkifdyaleqagnpdrsrvlmvgdtaesdilgginaglatcwlnahhreqpegiaptwtvsslheleqllckh]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=yjjG+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=yjjG]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
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Efficient in vitro substrates include: dUMP, UMP, and dTMP; phosphoramidase: in vitro activities demonstrated by Kuznetsova et al. (2005, 2006). yjjG mutants are sensitive to 5-fluoropyrimidine derivatives, such as 5-fluoro-2'-deoxyuridine (Titz, 2007). YjjG has a strict metal requirement for catalytic activity. Poorly utilized substrates include UDP, TDP and a variety of nucleotide monophosphates. A yjjG mutation blocks the utilization of thymine to feed a thyA auxotroph since it must first be converted to thymidine and dUMP dephosphorylated by YjjG is needed for that conversion (Weiss, 2006). YjjG is also called nucleoside 5'-monophosphate phosphohydrolase. HAD superfamily.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:40, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

yjjG

Gene Synonym(s)

ECK4365, b4374, JW4336[1], JW4336

Product Desc.

pyrimidine nucleotidase[2][3]

Noncanonical pyrimidine nucleotide house-cleaning phosphatase; dUMP phosphatase activity[4]

Product Synonyms(s)

predicted hydrolase [1], B4374 [2][1], YjjG [2][1] , ECK4365, JW4336, b4374

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): holD[2]

Regulation/Activity
Quick Links



        

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Notes

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Efficient in vitro substrates include: dUMP, UMP, and dTMP; phosphoramidase: in vitro activities demonstrated by Kuznetsova et al. (2005, 2006). yjjG mutants are sensitive to 5-fluoropyrimidine derivatives, such as 5-fluoro-2'-deoxyuridine (Titz, 2007). YjjG has a strict metal requirement for catalytic activity. Poorly utilized substrates include UDP, TDP and a variety of nucleotide monophosphates. A yjjG mutation blocks the utilization of thymine to feed a thyA auxotroph since it must first be converted to thymidine and dUMP dephosphorylated by YjjG is needed for that conversion (Weiss, 2006). YjjG is also called nucleoside 5'-monophosphate phosphohydrolase. HAD superfamily.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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