PMID:23090957: Difference between revisions
Fill PMID: Page! |
imported>Wikientrybot change PMID template to TableEdit version |
||
| (2 intermediate revisions by 2 users not shown) | |||
| Line 12: | Line 12: | ||
!align=left |Citation | !align=left |Citation | ||
|| | || | ||
'''Withman, B , Gunasekera, TS , Beesetty, P , Agans, R | '''Withman, B, Gunasekera, TS, Beesetty, P, Agans, R and Paliy, O''' (2013) Transcriptional responses of uropathogenic Escherichia coli to increased environmental osmolality caused by salt or urea. ''Infect. Immun.'' '''81''':80-9 | ||
|- | |- | ||
!align=left |Abstract | !align=left |Abstract | ||
| Line 31: | Line 31: | ||
|} | |} | ||
<!--box uid=d41d8cd98f00b204e9800998ecf8427e.182977.Q51560cc3a6de8--> | <!--box uid=d41d8cd98f00b204e9800998ecf8427e.182977.Q51560cc3a6de8--> | ||
==Significance {{HelpIcon|Help:Literature}} == | ==Significance {{HelpIcon|Help:Literature}} == | ||
{{LitSignificance}} | {{LitSignificance}} | ||
| Line 39: | Line 38: | ||
==Annotations {{HelpIcon|Help:Literature}}== | ==Annotations {{HelpIcon|Help:Literature}}== | ||
<protect>< | <protect><annotationlinks/></protect> | ||
==EcoliWiki Links {{HelpIcon|Help:Literature}} == | ==EcoliWiki Links {{HelpIcon|Help:Literature}} == | ||
| Line 63: | Line 48: | ||
{{RefHelp}} | {{RefHelp}} | ||
<references/> | <references/> | ||
[[Category:Expression data]] | |||
Latest revision as of 04:43, 15 September 2013
| Citation |
Withman, B, Gunasekera, TS, Beesetty, P, Agans, R and Paliy, O (2013) Transcriptional responses of uropathogenic Escherichia coli to increased environmental osmolality caused by salt or urea. Infect. Immun. 81:80-9 |
|---|---|
| Abstract |
Uropathogenic Escherichia coli (UPEC) is the most common causative agent of urinary tract infections in humans. The majority of urinary infections develop via ascending route through the urethra, where bacterial cells come in contact with human urine prior to reaching the bladder or kidneys. Since urine contains significant amounts of inorganic ions and urea, it imposes osmotic and denaturing stresses on bacterial cells. In this study, we determined the transcriptional adaptive responses of UPEC strain CFT073 to the presence of 0.3 M NaCl or 0.6 M urea in the growth medium. The cell responses to these two osmolytes were drastically different. Although most of the genes of the osmotically inducible regulon were overexpressed in medium with salt, urea failed to stimulate osmotic stress response. At the same time, UPEC colonization genes encoding type 1 and F1C fimbriae and capsule biosynthesis were transcriptionally induced in the presence of urea but did not respond to increased salt concentration. We speculate that urea can potentially be sensed by uropathogenic bacteria to initiate infection program. In addition, several molecular chaperone genes were overexpressed in the presence of urea, whereas adding NaCl to the medium led to an upregulation of a number of anaerobic metabolism pathways. |
| Links |
PubMed PMC3536127 Online version:10.1128/IAI.01049-12 |
| Keywords |
|
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
See also
References
See Help:References for how to manage references in EcoliWiki.