Bicyclomycin: Difference between revisions
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===Structure=== | ===Structure=== | ||
[[Image:bicyclomycin structure.gif]] | [[Image:bicyclomycin structure.gif]] | ||
NLM PubChem Public Chemical Database | |||
===Targets=== | ===Targets=== | ||
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|- | |- | ||
!|Gene!!Allele!!Sensitivity to BCM!!Reference | !|Gene!!Allele!!Sensitivity to BCM!!Reference | ||
|- | |||
| | |||
recA | |||
| | |||
deletion | |||
| | |||
increased senstivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
recO | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
rdgC | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
trxA | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
trxB | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
minC | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
envC | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
csgG | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
pgpB | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
yciB | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
ydcS | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
ydcX | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
degP | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
dnaK | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
hscA | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
lon | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
rimK | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
rplA | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
rpsF | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
rlmE | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
dapF | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
fabF | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
gpmM | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
iscS | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
ycjU | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
hns | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
yciT | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
rzpQ | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
ydfA | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
ymfT | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
ybaB | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
yciM | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
ydhT | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- | |||
| | |||
yebV | |||
| | |||
deletion | |||
| | |||
increased sensitivity | |||
| | |||
PMID:21357484 | |||
|- class="tableEdit_footer" | |- class="tableEdit_footer" | ||
Latest revision as of 14:18, 13 December 2011
Bicyclomycin, discovered in 1972, has a structure that is unique among antibiotics. Currently used to treat nonspecific diarrhea, it has a low toxicity, and no cross-resistance with other antibiotics has yet been found. It is effective against many Gram-negative bacteria. Bicyclomycin is also effective against the Gram-positive bacterium Micrococcus luteus.[1] It is the only known selective inhibitor of Rho.
Mode of Action
Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP.[1]
Structure
NLM PubChem Public Chemical Database
Targets
Bicyclomycin targets the transcription termination factor Rho.[2]
Mechanisms of Resistance
Mutations that affect sensitivity
Genes in E. coli that affect sensitivity to bicyclomycin.[3]
| Gene | Allele | Sensitivity to BCM | Reference |
|---|---|---|---|
|
recA |
deletion |
increased senstivity |
|
|
recO |
deletion |
increased sensitivity |
|
|
rdgC |
deletion |
increased sensitivity |
|
|
trxA |
deletion |
increased sensitivity |
|
|
trxB |
deletion |
increased sensitivity |
|
|
minC |
deletion |
increased sensitivity |
|
|
envC |
deletion |
increased sensitivity |
|
|
csgG |
deletion |
increased sensitivity |
|
|
pgpB |
deletion |
increased sensitivity |
|
|
yciB |
deletion |
increased sensitivity |
|
|
ydcS |
deletion |
increased sensitivity |
|
|
ydcX |
deletion |
increased sensitivity |
|
|
degP |
deletion |
increased sensitivity |
|
|
dnaK |
deletion |
increased sensitivity |
|
|
hscA |
deletion |
increased sensitivity |
|
|
lon |
deletion |
increased sensitivity |
|
|
rimK |
deletion |
increased sensitivity |
|
|
rplA |
deletion |
increased sensitivity |
|
|
rpsF |
deletion |
increased sensitivity |
|
|
rlmE |
deletion |
increased sensitivity |
|
|
dapF |
deletion |
increased sensitivity |
|
|
fabF |
deletion |
increased sensitivity |
|
|
gpmM |
deletion |
increased sensitivity |
|
|
iscS |
deletion |
increased sensitivity |
|
|
ycjU |
deletion |
increased sensitivity |
|
|
hns |
deletion |
increased sensitivity |
|
|
yciT |
deletion |
increased sensitivity |
|
|
rzpQ |
deletion |
increased sensitivity |
|
|
ydfA |
deletion |
increased sensitivity |
|
|
ymfT |
deletion |
increased sensitivity |
|
|
ybaB |
deletion |
increased sensitivity |
|
|
yciM |
deletion |
increased sensitivity |
|
|
ydhT |
deletion |
increased sensitivity |
|
|
yebV |
deletion |
increased sensitivity |
|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 Kohn, H & Widger, W (2005) The molecular basis for the mode of action of bicyclomycin. Curr Drug Targets Infect Disord 5 273-95 PubMed
- ↑ Zwiefka, A et al. (1993) Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli. Biochemistry 32 3564-70 PubMed
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 Tran, L et al. (2011) Single-gene deletion mutants of Escherichia coli with altered sensitivity to bicyclomycin, an inhibitor of transcription termination factor Rho. J. Bacteriol. 193 2229-35 PubMed