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Bicyclomycin, discovered in 1972, has a structure that is unique among antibiotics. Currently used to treat nonspecific diarrhea, it has a low toxicity, and no cross-resistance with other antibiotics has yet been found. It is effective against many Gram-negative bacteria. Bicyclomycin is also effective against the Gram-positive bacterium ''Micrococcus luteus''.<ref name='PMID:16181146'/> It is the only known selective inhibitor of Rho.
===Mode of Action===
Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP.<ref name='PMID:16181146'/>
===Structure===
[[Image:bicyclomycin structure.gif]]
NLM PubChem Public Chemical Database
===Targets===
Bicyclomycin targets the transcription termination factor Rho.<ref name='PMID:8466900'/>
===Mechanisms of Resistance===
===Mutations that affect sensitivity===
Genes in ''E. coli'' that affect sensitivity to bicyclomycin.<ref name='PMID:21357484'/>
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!|Gene!!Allele!!Sensitivity to BCM!!Reference
|-
|
recA
|
deletion
|
increased senstivity
|
PMID:21357484
|-
|
recO
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
rdgC
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
trxA
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
trxB
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
minC
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
envC
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
csgG
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
pgpB
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
yciB
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
ydcS
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
ydcX
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
degP
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
dnaK
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
hscA
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
lon
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
rimK
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
rplA
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
rpsF
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
rlmE
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
dapF
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
fabF
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
gpmM
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
iscS
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
ycjU
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
hns
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
yciT
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
rzpQ
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
ydfA
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
ymfT
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
ybaB
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
yciM
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
ydhT
|
deletion
|
increased sensitivity
|
PMID:21357484
|-
|
yebV
|
deletion
|
increased sensitivity
|
PMID:21357484
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==References==
==References==
{{RefHelp}}
{{RefHelp}}
<references/>
<references/>
__NOTOC__
to add a reference:  Genes in E. coli that affect sensitivity to bicyclomycin.<ref name='PMID:21357484'/>

Latest revision as of 14:18, 13 December 2011

Bicyclomycin, discovered in 1972, has a structure that is unique among antibiotics. Currently used to treat nonspecific diarrhea, it has a low toxicity, and no cross-resistance with other antibiotics has yet been found. It is effective against many Gram-negative bacteria. Bicyclomycin is also effective against the Gram-positive bacterium Micrococcus luteus.[1] It is the only known selective inhibitor of Rho.


Mode of Action

Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP.[1]

Structure

NLM PubChem Public Chemical Database

Targets

Bicyclomycin targets the transcription termination factor Rho.[2]

Mechanisms of Resistance

Mutations that affect sensitivity

Genes in E. coli that affect sensitivity to bicyclomycin.[3]

Gene Allele Sensitivity to BCM Reference

recA

deletion

increased senstivity

PMID:21357484[3]

recO

deletion

increased sensitivity

PMID:21357484[3]

rdgC

deletion

increased sensitivity

PMID:21357484[3]

trxA

deletion

increased sensitivity

PMID:21357484[3]

trxB

deletion

increased sensitivity

PMID:21357484[3]

minC

deletion

increased sensitivity

PMID:21357484[3]

envC

deletion

increased sensitivity

PMID:21357484[3]

csgG

deletion

increased sensitivity

PMID:21357484[3]

pgpB

deletion

increased sensitivity

PMID:21357484[3]

yciB

deletion

increased sensitivity

PMID:21357484[3]

ydcS

deletion

increased sensitivity

PMID:21357484[3]

ydcX

deletion

increased sensitivity

PMID:21357484[3]

degP

deletion

increased sensitivity

PMID:21357484[3]

dnaK

deletion

increased sensitivity

PMID:21357484[3]

hscA

deletion

increased sensitivity

PMID:21357484[3]

lon

deletion

increased sensitivity

PMID:21357484[3]

rimK

deletion

increased sensitivity

PMID:21357484[3]

rplA

deletion

increased sensitivity

PMID:21357484[3]

rpsF

deletion

increased sensitivity

PMID:21357484[3]

rlmE

deletion

increased sensitivity

PMID:21357484[3]

dapF

deletion

increased sensitivity

PMID:21357484[3]

fabF

deletion

increased sensitivity

PMID:21357484[3]

gpmM

deletion

increased sensitivity

PMID:21357484[3]

iscS

deletion

increased sensitivity

PMID:21357484[3]

ycjU

deletion

increased sensitivity

PMID:21357484[3]

hns

deletion

increased sensitivity

PMID:21357484[3]

yciT

deletion

increased sensitivity

PMID:21357484[3]

rzpQ

deletion

increased sensitivity

PMID:21357484[3]

ydfA

deletion

increased sensitivity

PMID:21357484[3]

ymfT

deletion

increased sensitivity

PMID:21357484[3]

ybaB

deletion

increased sensitivity

PMID:21357484[3]

yciM

deletion

increased sensitivity

PMID:21357484[3]

ydhT

deletion

increased sensitivity

PMID:21357484[3]

yebV

deletion

increased sensitivity

PMID:21357484[3]


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References

See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 Kohn, H & Widger, W (2005) The molecular basis for the mode of action of bicyclomycin. Curr Drug Targets Infect Disord 5 273-95 PubMed
  2. ↑ Zwiefka, A et al. (1993) Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli. Biochemistry 32 3564-70 PubMed
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 Tran, L et al. (2011) Single-gene deletion mutants of Escherichia coli with altered sensitivity to bicyclomycin, an inhibitor of transcription termination factor Rho. J. Bacteriol. 193 2229-35 PubMed
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