hflC:Quickview: Difference between revisions

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{{Tab On|Quickview|hflC}}{{Tab|Gene|hflC}}{{Tab|Gene Product(s)|hflC}}{{Tab|Expression|hflC}}{{Tab|Evolution|hflC}}{{Tab|On One Page|hflC}}{{TabsBottom}}
{{Tab On|Quickview|hflC}}{{Tab|Gene|hflC}}{{Tab|Gene Product(s)|hflC}}{{Tab|Expression|hflC}}{{Tab|Evolution|hflC}}{{Tab|On One Page|hflC}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[hflC:Gene|''hflC]]'' (synonyms: ''ECK4171, b4175, JW4133, hflA'')<ref name='LIB:Riley_2006'/>
''hflC''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[hflC:Gene_Product(s)|HflC product]]<ref name='LIB:Riley_2006'/>: modulator for HflB protease specific for phage lambda cII repressor<ref name='LIB:Riley_2006'/>, B4175<ref name='LIB:EcoCyc10.6'/>, HflA<ref name='LIB:EcoCyc10.6'/>, HflC<ref name='LIB:EcoCyc10.6'/>, [[:Category:Complex:HflK-HflC complex; regulator of FtsH protease|HflK-HflC complex; regulator of FtsH protease]]<ref name='LIB:EcoCyc11.1'/>, [[:Category:Complex:HflB, integral membrane ATP-dependent zinc metallopeptidase|HflB, integral membrane ATP-dependent zinc metallopeptidase]]<ref name='LIB:EcoCyc11.1'/>
''ECK4171, b4175, JW4133, hflA''<ref name='LIB:Riley_2006'/>, hflA''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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regulator of FtsH protease<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
regulator of FtsH protease<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:HflK-HflC complex; regulator of FtsH protease|HflK-HflC complex; regulator of FtsH protease]]<ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:HflB, integral membrane ATP-dependent zinc metallopeptidase|HflB, integral membrane ATP-dependent zinc metallopeptidase]]<ref name='LIB:EcoCyc11.1'/>


Membrane bound protease complex, with FtsH and HflK; regulates lysogeny; non-essential<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''modulator for HflB protease specific for phage lambda cII repressor<ref name='LIB:Riley_2006'/>, B4175<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HflA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HflC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK4171, hflA, JW4133, b4175''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:yjeFE-amiB-mutL-miaA-hfq-hflXKC|yjeFE-amiB-mutL-miaA-hfq-hflXKC]]<ref name='LIB:EcoCyc10.6'/>, ORF55-ORF17-amiB-mutL-miaA-hfq-hflXKC  
transcription unit(s): [[:Category:Txn_unit:yjeFE-amiB-mutL-miaA-hfq-hflXKC|yjeFE-amiB-mutL-miaA-hfq-hflXKC]]<ref name='LIB:EcoCyc10.6'/>, ORF55-ORF17-amiB-mutL-miaA-hfq-hflXKC  
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!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=hflC&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10435]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000428&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=hflC&loc=MG1655%3A4401323..4402327,W3110%3A4407980..4408984,REL606%3A4381455..4382459,DH10B%3A4501685..4502689,BW2952%3A4340058..4341062]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=4340058&end=4341062&gene=hflC&aa=mrksviaiiiivlvvlymsvfvvkegergitlrfgkvlrdddnkplvyepglhfkipfietvkmldariqtmdnqadrfvtkekkdlivdsyikwrisdfsryylatgggdisqaevllkrkfsdrlrseigrldvkdivtdsrgrltlevrdalnsgsagtedevttpaadnaiaeaaervtaetkgkvpvinpnsmaalgievvdvrikqinlptevseaiynrmraereavarrhrsqgqeeaeklratadyevtrtlaeaerqgrimrgegdaeaaklfadafskdpdfyafirslrayensfsgnqdvmvmspdsdffrymktptsatr]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=hflC+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=hflC]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
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Gain-of-function alleles in hflC and hflK inhibit FtsH-mediated degradation of uncomplexed SecY protein and other membrane protein substrates. Null hflC or hflK alleles stabilize cytoplasmic substrate cII. hflCK is a multicopy suppressor of ftsH htpX double mutant. Serine protease-like motif in HflC not required for  cII degradation. HflC and HflK have a periplasmic prohibitin homology (PHB) domain. HT_Cmplx45_Mem: HflC+HybC+BamB.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:54, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

hflC

Gene Synonym(s)

ECK4171, b4175, JW4133, hflA[1], hflA

Product Desc.

regulator of FtsH protease[2][3];

Component of HflK-HflC complex; regulator of FtsH protease[3]; HflB, integral membrane ATP-dependent zinc metallopeptidase[3]

Membrane bound protease complex, with FtsH and HflK; regulates lysogeny; non-essential[4]

Product Synonyms(s)

modulator for HflB protease specific for phage lambda cII repressor[1], B4175[2][1], HflA[2][1], HflC[2][1] , ECK4171, hflA, JW4133, b4175

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): yjeFE-amiB-mutL-miaA-hfq-hflXKC[2], ORF55-ORF17-amiB-mutL-miaA-hfq-hflXKC

Regulation/Activity
Quick Links



        

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Notes

[back to top]


Gain-of-function alleles in hflC and hflK inhibit FtsH-mediated degradation of uncomplexed SecY protein and other membrane protein substrates. Null hflC or hflK alleles stabilize cytoplasmic substrate cII. hflCK is a multicopy suppressor of ftsH htpX double mutant. Serine protease-like motif in HflC not required for cII degradation. HflC and HflK have a periplasmic prohibitin homology (PHB) domain. HT_Cmplx45_Mem: HflC+HybC+BamB.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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