alkB:Quickview: Difference between revisions
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* ** PLEASE DON'T EDIT THIS TABLE DIRECTLY. Use the edit table link under the table. ** | * ** PLEASE DON'T EDIT THIS TABLE DIRECTLY. Use the edit table link under the table. ** | ||
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!align=left {{table_heading_style}} |Gene Synonym(s) | !align=left {{table_heading_style}} |Gene Synonym(s) | ||
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''ECK2204, b2212, JW2200, aidD''<ref name='LIB:Riley_2006'/> | ''ECK2204, b2212, JW2200, aidD''<ref name='LIB:Riley_2006'/>, aidD'' | ||
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!align=left {{table_heading_style}} |Product Desc. | !align=left {{table_heading_style}} |Product Desc. | ||
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!align=left {{table_heading_style}} |Product Synonyms(s) | !align=left {{table_heading_style}} |Product Synonyms(s) | ||
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oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions<ref name='LIB:Riley_2006'/>, B2212<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AidD<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AlkB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | ''oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions<ref name='LIB:Riley_2006'/>, B2212<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AidD<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AlkB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , aidD, ECK2204, JW2200, b2212'' | ||
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!align=left {{table_heading_style}} |Function from GO | !align=left {{table_heading_style}} |Function from GO | ||
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!align=left {{table_heading_style}} |Quick Links | !align=left {{table_heading_style}} |Quick Links | ||
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[http://ecoliwiki.net/tools/display_dna.php?gene=alkB&loc=MG1655 | [[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=alkB&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10037]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000034&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=alkB&loc=MG1655%3A2307363..2306713,W3110%3A2312675..2312025,REL606%3A2259445..2258795,DH10B%3A2398351..2397701,BW2952%3A2192518..2193168]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2192518&end=2193168&gene=alkB&aa=mldlfadaepwqeplaagavilrrfafnaaeqlirdindvasqspfrqmvtpggytmsvamtncghlgwtthrqgylyspidpqtnkpwpampqsfhnlcqraataagypdfqpdaclinryapgaklslhqdkdepdlrapivsvslglpaifqfgglkrndplkrlllehgdvvvwggesrlfyhgiqplkagfhpltidcrynltfrqagkke]] [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=alkB+AND+escherichia+coli]] [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=alkB]] | ||
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Latest revision as of 21:53, 27 May 2013
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Standard Name |
alkB |
|---|---|
| Gene Synonym(s) |
ECK2204, b2212, JW2200, aidD[1], aidD |
| Product Desc. |
AlkB repair system for alkylated DNA and RNA[2][3] Alkylated DNA repair enzyme; alpha-ketoglutarate- and Fe(II)-dependent dioxygenase[4]; releases replication blocks by oxidative demethylation of 1-methyladenine and 3-methylcytosine residues in ssDNA and dsDNA[5] |
| Product Synonyms(s) |
oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions[1], B2212[2][1], AidD[2][1], AlkB[2][1] , aidD, ECK2204, JW2200, b2212 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
|
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
AlkB mutants are extremely sensitive to MMS. Also repairs alkylated mRNA and tRNA in vivo and in vitro, the first example of direct RNA repair. Repairs epsilonA and epsilonC. Ada regulon.[6]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Falnes, PØ et al. (2002) AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419 178-82 PubMed
- ↑ Trewick, SC et al. (2002) Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419 174-8 PubMed
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.