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{{Tab On|Quickview|tadA}}{{Tab|Gene|tadA}}{{Tab|Gene Product(s)|tadA}}{{Tab|Expression|tadA}}{{Tab|Evolution|tadA}}{{Tab|On One Page|tadA}}{{TabsBottom}}
{{Tab On|Quickview|tadA}}{{Tab|Gene|tadA}}{{Tab|Gene Product(s)|tadA}}{{Tab|Expression|tadA}}{{Tab|Evolution|tadA}}{{Tab|On One Page|tadA}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[tadA:Gene|''tadA]]'' (synonyms: ''ECK2557, b2559, JW2543, yfhC'')<ref name='LIB:Riley_2006'/>
''tadA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[tadA:Gene_Product(s)|TadA product]]<ref name='LIB:Riley_2006'/>: tRNA-specific adenosine deaminase<ref name='LIB:Riley_2006'/>, TadA<ref name='LIB:EcoCyc10.6'/>, YfhC<ref name='LIB:EcoCyc10.6'/>, B2559<ref name='LIB:EcoCyc10.6'/>, [[:Category:Complex:tRNA-specific adenosine deaminase|tRNA-specific adenosine deaminase]]<ref name='LIB:EcoCyc11.1'/>
''ECK2557, b2559, JW2543, yfhC''<ref name='LIB:Riley_2006'/>, yfhC''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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TadA; monomer of tRNA specific adenosine deaminase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
TadA; of tRNA specific adenosine deaminase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:tRNA-specific adenosine deaminase|tRNA-specific adenosine deaminase]]<ref name='LIB:EcoCyc11.1'/>


A34-tRNA adenosine deaminase; point mutation confers resistance to HokC(Gef)-mediated cell killing; essential gene; homodimeric<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''tRNA-specific adenosine deaminase<ref name='LIB:Riley_2006'/>, TadA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YfhC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, B2559<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK2557, JW2543, yfhC, b2559''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:tadA|tadA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:tadA|tadA]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=tadA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11372]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120001340&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=tadA&loc=MG1655%3A2695912..2695376,W3110%3A2696546..2696010,DH10B%3A2787644..2787141,REL606%3A2619382..2618846,BW2952%3A2581181..2581684]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2581181&end=2581684&gene=tadA&aa=mrrafitgvfflsevefsheywmrhaltlakrawderevpvgavlvhnnrvigegwnrpigrhdptahaeimalrqgglvmqnyrlidatlyvtlepcvmcagamihsrigrvvfgardaktgaagslmdvlhhpgmnhrveitegiladecaallsdffrmrrqeikaqkkaqsstd]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=tadA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=tadA]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
Previously reported non-essential nature was mistakenly based on an insertion that removed the last 17 aa, but the truncated enzyme is active. Three possible start sites annotated in various orthologs: -11, +1, and +12; alignment results ambiguous; +1 chosen due to best RBS.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:45, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

tadA

Gene Synonym(s)

ECK2557, b2559, JW2543, yfhC[1], yfhC

Product Desc.

TadA; of tRNA specific adenosine deaminase[2][3];

Component of tRNA-specific adenosine deaminase[3]

A34-tRNA adenosine deaminase; point mutation confers resistance to HokC(Gef)-mediated cell killing; essential gene; homodimeric[4]

Product Synonyms(s)

tRNA-specific adenosine deaminase[1], TadA[2][1], YfhC[2][1], B2559[2][1] , ECK2557, JW2543, yfhC, b2559

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): tadA[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


Previously reported non-essential nature was mistakenly based on an insertion that removed the last 17 aa, but the truncated enzyme is active. Three possible start sites annotated in various orthologs: -11, +1, and +12; alignment results ambiguous; +1 chosen due to best RBS.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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