PMID:9303418: Difference between revisions

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<span style = 'font-size: large'> '''Riesenfeld, C, Everett, M, Piddock, LJ and Hall, BG'''  (1997) Adaptive mutations produce resistance to ciprofloxacin.''Antimicrob. Agents Chemother.'' '''41''':2059-60</span>
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!align=left  |Citation
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'''Riesenfeld, C, Everett, M, Piddock, LJ and Hall, BG'''  (1997) Adaptive mutations produce resistance to ciprofloxacin. ''Antimicrob. Agents Chemother.'' '''41''':2059-60
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!align=left  |Abstract
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Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9303418 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164069 PMC164069]


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|{{TableHeadingColor}} |'''Abstract''' || Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.
!align=left  |Keywords
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Adaptation, Physiological; Anti-Infective Agents/pharmacology; Ciprofloxacin/pharmacology; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/growth & development; Microbial Sensitivity Tests; Mutation
|{{TableHeadingColor}} nowrap |'''Links''' ||  [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9303418 PubMed]
 
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!|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status
 
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==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
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Latest revision as of 04:58, 15 September 2013

Citation

Riesenfeld, C, Everett, M, Piddock, LJ and Hall, BG (1997) Adaptive mutations produce resistance to ciprofloxacin. Antimicrob. Agents Chemother. 41:2059-60

Abstract

Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.

Links

PubMed PMC164069

Keywords

Adaptation, Physiological; Anti-Infective Agents/pharmacology; Ciprofloxacin/pharmacology; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/growth & development; Microbial Sensitivity Tests; Mutation

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