PMID:7517486: Difference between revisions
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''' | '''Chow, J and Dennis, PP''' (1994) Coupling between mRNA synthesis and mRNA stability in Escherichia coli. ''Mol. Microbiol.'' '''11''':919-31 | ||
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!align=left |Abstract | !align=left |Abstract | ||
Latest revision as of 04:50, 15 September 2013
| Citation |
Chow, J and Dennis, PP (1994) Coupling between mRNA synthesis and mRNA stability in Escherichia coli. Mol. Microbiol. 11:919-31 |
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| Abstract |
Transiently stable products derived from the endonuclease cleavage of transcripts from the secEnusG and rplKAJLrpoBC operons have been identified. Cleavage sites for RNase III occur in the leader of the secEnusG transcript and in the L12-beta intercistronic space of the rplKAJLrpoBC transcript. A single RNase E cleavage site was located in the L1-L10 intergenic space. Inactivation of RNase III and RNase E results respectively in a one- to twofold and a greater than 10-fold stabilization of five mRNA sequences from within the secE, nusG, L11-L1, L10 and beta encoding cistrons. The relative amounts of each of these five mRNA sequences were found to be nearly constant when measured either in the presence or absence of cleavage by RNase III or RNase E. This clearly implies that any increases in the stability of these mRNA sequences resulting from the inactivation of processing by RNase III or RNAase E are counterbalanced by changes in the mRNA synthesis rates. The mechanism that links mRNA synthesis to mRNA decay is not known. |
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| Keywords |
Bacterial Proteins/metabolism; Base Sequence; Endoribonucleases/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Nucleic Acid Conformation; Protein Biosynthesis; RNA Processing, Post-Transcriptional; RNA, Bacterial/metabolism; RNA, Messenger/metabolism; Ribonuclease III; Transcription, Genetic |
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