PMID:4945194: Difference between revisions

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<span style = 'font-size: large'> '''Fradkin, JE and Fraenkel, DG'''  (1971) 2-keto-3-deoxygluconate 6-phosphate aldolase mutants of Escherichia coli.''J. Bacteriol.'' '''108''':1277-83</span>
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!align=left  |Citation
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'''Fradkin, JE and Fraenkel, DG'''  (1971) 2-keto-3-deoxygluconate 6-phosphate aldolase mutants of Escherichia coli. ''J. Bacteriol.'' '''108''':1277-83
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!align=left  |Abstract
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A new mutation in Escherichia coli, giving inability to grow on gluconic, glucuronic, or galacturonic acids, has been identified as complete deficiency of 2-keto-3-deoxygluconate 6-phosphate (KDGP) aldolase activity. The genetic map position of the locus, eda, is about 35 min. The inability to grow on the uronic acids was expected, because the aldolase is on the sole known pathway of their metabolism. However, inability to grow on gluconate was less expected, because the hexose monophosphate shunt might be used, as happens in mutants blocked in the previous step, edd, of the Entner-Doudoroff pathway. The likely explanation of gluconate negativity is inhibition by accumulated KDGP, because gluconate is inhibitory to growth on other substances, and one type of gluconate revertant is eda(-), edd(-). KDGP is probably the inducer of KDGP aldolase.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=4945194 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC247215 PMC247215]


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|{{TableHeadingColor}} |'''Abstract''' || A new mutation in Escherichia coli, giving inability to grow on gluconic, glucuronic, or galacturonic acids, has been identified as complete deficiency of 2-keto-3-deoxygluconate 6-phosphate (KDGP) aldolase activity. The genetic map position of the locus, eda, is about 35 min. The inability to grow on the uronic acids was expected, because the aldolase is on the sole known pathway of their metabolism. However, inability to grow on gluconate was less expected, because the hexose monophosphate shunt might be used, as happens in mutants blocked in the previous step, edd, of the Entner-Doudoroff pathway. The likely explanation of gluconate negativity is inhibition by accumulated KDGP, because gluconate is inhibitory to growth on other substances, and one type of gluconate revertant is eda(-), edd(-). KDGP is probably the inducer of KDGP aldolase.
!align=left  |Keywords
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Alcohol Oxidoreductases/metabolism; Arabinose/metabolism; Cell-Free System; Chromosome Mapping; Conjugation, Genetic; Culture Media; Enzyme Induction; Escherichia coli/enzymology; Escherichia coli/growth & development; Escherichia coli/metabolism; Genes; Genetics, Microbial; Gluconates/metabolism; Glucose/metabolism; Glucuronates/metabolism; Hydro-Lyases/metabolism; L-Serine Dehydratase/metabolism; Mannitol/metabolism; Mutation; Phosphotransferases/metabolism; Recombination, Genetic; Spectrophotometry; Succinates/metabolism; Transduction, Genetic; Uronic Acids/metabolism
|{{TableHeadingColor}} nowrap |'''Links''' ||  [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=4945194 PubMed]
 
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==Significance {{HelpIcon|Help:Literature}} ==
==Significance {{HelpIcon|Help:Literature}} ==
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==Annotations {{HelpIcon|Help:Literature}}==
==Annotations {{HelpIcon|Help:Literature}}==
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!Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status
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KDPG
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GO:0008675
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2-dehydro-3-deoxy-phosphogluconate aldolase activity
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IMP: Inferred from Mutant Phenotype
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F
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An IMP evidence code is noted from Table 1. p.1279 due to absence of activity in mutant.
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complete
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==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
==EcoliWiki Links {{HelpIcon|Help:Literature}} ==

Latest revision as of 04:48, 15 September 2013

Citation

Fradkin, JE and Fraenkel, DG (1971) 2-keto-3-deoxygluconate 6-phosphate aldolase mutants of Escherichia coli. J. Bacteriol. 108:1277-83

Abstract

A new mutation in Escherichia coli, giving inability to grow on gluconic, glucuronic, or galacturonic acids, has been identified as complete deficiency of 2-keto-3-deoxygluconate 6-phosphate (KDGP) aldolase activity. The genetic map position of the locus, eda, is about 35 min. The inability to grow on the uronic acids was expected, because the aldolase is on the sole known pathway of their metabolism. However, inability to grow on gluconate was less expected, because the hexose monophosphate shunt might be used, as happens in mutants blocked in the previous step, edd, of the Entner-Doudoroff pathway. The likely explanation of gluconate negativity is inhibition by accumulated KDGP, because gluconate is inhibitory to growth on other substances, and one type of gluconate revertant is eda(-), edd(-). KDGP is probably the inducer of KDGP aldolase.

Links

PubMed PMC247215

Keywords

Alcohol Oxidoreductases/metabolism; Arabinose/metabolism; Cell-Free System; Chromosome Mapping; Conjugation, Genetic; Culture Media; Enzyme Induction; Escherichia coli/enzymology; Escherichia coli/growth & development; Escherichia coli/metabolism; Genes; Genetics, Microbial; Gluconates/metabolism; Glucose/metabolism; Glucuronates/metabolism; Hydro-Lyases/metabolism; L-Serine Dehydratase/metabolism; Mannitol/metabolism; Mutation; Phosphotransferases/metabolism; Recombination, Genetic; Spectrophotometry; Succinates/metabolism; Transduction, Genetic; Uronic Acids/metabolism

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