PMID:21402902: Difference between revisions
Fill PMID: Page! |
imported>Wikientrybot change PMID template to TableEdit version |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{RightTOC}} | {{RightTOC}} | ||
< | <!--box uid=d41d8cd98f00b204e9800998ecf8427e.179596.E5223918bcf90a--> | ||
< | <!-- | ||
****************************************************************************************** | |||
* | |||
* ** PLEASE DON'T EDIT THIS TABLE DIRECTLY. Use the edit table link under the table. ** | |||
* | |||
****************************************************************************************** --> | |||
{| id="E5223918bcf90a" class=" tableEdit PMID_info_table" | |||
|- | |- | ||
| | !align=left |Citation | ||
|| | |||
'''Lemke, JJ, Sanchez-Vazquez, P, Burgos, HL, Hedberg, G, Ross, W and Gourse, RL''' (2011) Direct regulation of Escherichia coli ribosomal protein promoters by the transcription factors ppGpp and DksA. ''Proc. Natl. Acad. Sci. U.S.A.'' '''108''':5712-7 | |||
|- | |- | ||
| | !align=left |Abstract | ||
|| | |||
We show here that the promoters for many of the Escherichia coli ribosomal protein operons are regulated directly by two transcription factors, the small RNA polymerase-binding protein DksA and the nutritional stress-induced nucleotide ppGpp. ppGpp and DksA work together to inhibit transcription initiation from ribosomal protein promoters in vitro and in vivo. The degree of promoter regulation by ppGpp/DksA varies among the r-protein promoters, but some are inhibited almost as much as rRNA promoters. Thus, many r-protein operons are regulated at the level of transcription in addition to their control by the classic translational feedback systems discovered ~30 y ago. We conclude that direct control of r-protein promoters and rRNA promoters by the same signal, ppGpp/DksA, makes a major contribution to the balanced and coordinated synthesis rates of all of the ribosomal components. | |||
|- | |||
!align=left |Links | |||
|| | |||
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21402902 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078377 PMC3078377] | |||
Online version:[http://dx.doi.org/10.1073/pnas.1019383108 10.1073/pnas.1019383108] | Online version:[http://dx.doi.org/10.1073/pnas.1019383108 10.1073/pnas.1019383108] | ||
|- | |||
!align=left |Keywords | |||
|| | |||
Escherichia coli/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial/genetics; Plasmids/genetics; Promoter Regions, Genetic/genetics; Pyrophosphatases/metabolism; Ribosomal Proteins/genetics; Transcription Factors/metabolism; beta-Galactosidase | |||
|- class="tableEdit_footer" | |||
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=d41d8cd98f00b204e9800998ecf8427e.179596.E5223918bcf90a&page=179596&pagename={{FULLPAGENAMEE}}&type=1&template=PMID_info_table edit table]</span> || | |||
|} | |} | ||
< | <!--box uid=d41d8cd98f00b204e9800998ecf8427e.179596.E5223918bcf90a--> | ||
==Significance {{HelpIcon|Help:Literature}} == | ==Significance {{HelpIcon|Help:Literature}} == | ||
{{LitSignificance}} | {{LitSignificance}} | ||
| Line 19: | Line 38: | ||
==Annotations {{HelpIcon|Help:Literature}}== | ==Annotations {{HelpIcon|Help:Literature}}== | ||
<protect>< | <protect><annotationlinks/></protect> | ||
==EcoliWiki Links {{HelpIcon|Help:Literature}} == | ==EcoliWiki Links {{HelpIcon|Help:Literature}} == | ||
Latest revision as of 04:38, 15 September 2013
| Citation |
Lemke, JJ, Sanchez-Vazquez, P, Burgos, HL, Hedberg, G, Ross, W and Gourse, RL (2011) Direct regulation of Escherichia coli ribosomal protein promoters by the transcription factors ppGpp and DksA. Proc. Natl. Acad. Sci. U.S.A. 108:5712-7 |
|---|---|
| Abstract |
We show here that the promoters for many of the Escherichia coli ribosomal protein operons are regulated directly by two transcription factors, the small RNA polymerase-binding protein DksA and the nutritional stress-induced nucleotide ppGpp. ppGpp and DksA work together to inhibit transcription initiation from ribosomal protein promoters in vitro and in vivo. The degree of promoter regulation by ppGpp/DksA varies among the r-protein promoters, but some are inhibited almost as much as rRNA promoters. Thus, many r-protein operons are regulated at the level of transcription in addition to their control by the classic translational feedback systems discovered ~30 y ago. We conclude that direct control of r-protein promoters and rRNA promoters by the same signal, ppGpp/DksA, makes a major contribution to the balanced and coordinated synthesis rates of all of the ribosomal components. |
| Links |
PubMed PMC3078377 Online version:10.1073/pnas.1019383108 |
| Keywords |
Escherichia coli/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial/genetics; Plasmids/genetics; Promoter Regions, Genetic/genetics; Pyrophosphatases/metabolism; Ribosomal Proteins/genetics; Transcription Factors/metabolism; beta-Galactosidase |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
See also
References
See Help:References for how to manage references in EcoliWiki.