PMID:15817302: Difference between revisions

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<span style = 'font-size: large'> '''Eide, EJ, Kang, H, Crapo, S, Gallego, M and Virshup, DM'''  (2005) Casein kinase I in the Mammalian circadian clock.''Meth. Enzymol.'' '''393''':408-18</span>
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|{{TableHeadingColor}} |'''Abstract''' || The circadian clock is characterized by daily fluctuations in gene expression, protein abundance, and posttranslational modification of regulatory proteins. The Drosophila PERIOD (dPER) protein is phosphorylated by the serine?threonine protein kinase, DOUBLETIME (DBT). Similarly, the murine PERIOD proteins, mPER1 and mPER2, are phosphorylated by casein kinase I (CKI), the mammalian homolog of DBT. CKI also phosphorylates and partially activates the transcription factor BMAL1. Given the variety of potential targets for CKI and other cellular kinases, the precise role of phosphorylation is likely to be a complex one. Biochemical analysis of these and other circadian regulatory proteins has proven to be a fruitful approach in determining how they function within the context of the molecular clockworks.
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'''Eide, EJ, Kang, H, Crapo, S, Gallego, M and Virshup, DM'''  (2005) Casein kinase I in the mammalian circadian clock. ''Meth. Enzymol.'' '''393''':408-18
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The circadian clock is characterized by daily fluctuations in gene expression, protein abundance, and posttranslational modification of regulatory proteins. The Drosophila PERIOD (dPER) protein is phosphorylated by the serine?threonine protein kinase, DOUBLETIME (DBT). Similarly, the murine PERIOD proteins, mPER1 and mPER2, are phosphorylated by casein kinase I epsilon (CKI), the mammalian homolog of DBT. CKIepsilon also phosphorylates and partially activates the transcription factor BMAL1. Given the variety of potential targets for CKIepsilon and other cellular kinases, the precise role of phosphorylation is likely to be a complex one. Biochemical analysis of these and other circadian regulatory proteins has proven to be a fruitful approach in determining how they function within the context of the molecular clockworks.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15817302 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513158 PMC1513158]
Online version:[http://dx.doi.org/10.1016/S0076-6879(05)93019-X 10.1016/S0076-6879(05)93019-X]
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|{{TableHeadingColor}} nowrap |'''Links''' ||  [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15817302 PubMed]
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Alkaline Phosphatase/antagonists & inhibitors; Animals; Biological Clocks/genetics; Biological Clocks/physiology; Casein Kinase Iepsilon/genetics; Casein Kinase Iepsilon/metabolism; Cell Cycle Proteins/isolation & purification; Cell Cycle Proteins/metabolism; Cell Line; Humans; Mice; Nuclear Proteins/isolation & purification; Nuclear Proteins/metabolism; Oxazoles/pharmacology; Period Circadian Proteins; Transcription Factors/isolation & purification; Transcription Factors/metabolism; Transfection; Xenopus laevis
 
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Latest revision as of 04:27, 15 September 2013

Citation

Eide, EJ, Kang, H, Crapo, S, Gallego, M and Virshup, DM (2005) Casein kinase I in the mammalian circadian clock. Meth. Enzymol. 393:408-18

Abstract

The circadian clock is characterized by daily fluctuations in gene expression, protein abundance, and posttranslational modification of regulatory proteins. The Drosophila PERIOD (dPER) protein is phosphorylated by the serine?threonine protein kinase, DOUBLETIME (DBT). Similarly, the murine PERIOD proteins, mPER1 and mPER2, are phosphorylated by casein kinase I epsilon (CKI), the mammalian homolog of DBT. CKIepsilon also phosphorylates and partially activates the transcription factor BMAL1. Given the variety of potential targets for CKIepsilon and other cellular kinases, the precise role of phosphorylation is likely to be a complex one. Biochemical analysis of these and other circadian regulatory proteins has proven to be a fruitful approach in determining how they function within the context of the molecular clockworks.

Links

PubMed PMC1513158 Online version:10.1016/S0076-6879(05)93019-X

Keywords

Alkaline Phosphatase/antagonists & inhibitors; Animals; Biological Clocks/genetics; Biological Clocks/physiology; Casein Kinase Iepsilon/genetics; Casein Kinase Iepsilon/metabolism; Cell Cycle Proteins/isolation & purification; Cell Cycle Proteins/metabolism; Cell Line; Humans; Mice; Nuclear Proteins/isolation & purification; Nuclear Proteins/metabolism; Oxazoles/pharmacology; Period Circadian Proteins; Transcription Factors/isolation & purification; Transcription Factors/metabolism; Transfection; Xenopus laevis

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