frmB:Quickview: Difference between revisions

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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[frmB:Gene|''frmB]]'' (synonyms: ''ECK0352, b0355, JW0346, yaiM'')<ref name='LIB:Riley_2006'/>
''frmB''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[frmB:Gene_Product(s)|FrmB product]]<ref name='LIB:Riley_2006'/>: predicted esterase product, B0355 product, YaiM product
''ECK0352, b0355, JW0346, yaiM''<ref name='LIB:Riley_2006'/>, yaiM''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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<i>S</i>-formylglutathione hydrolase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
<i>S</i>-formylglutathione hydrolase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


S-formylglutathione hydrolase, formaldehyde degradation<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''predicted esterase<ref name='LIB:Riley_2006'/>, B0355<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YaiM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FrmB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0352, JW0346, yaiM, b0355''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:frmB|frmB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:frmB|frmB]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=frmB&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6208]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120002822&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=frmB&loc=MG1655%3A377592..376759,W3110%3A377592..376759,DH10B%3A316923..316090,REL606%3A350726..349893,BW2952%3A279518..280351]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=279518&end=280351&gene=frmB&aa=meliekhvsfggwqnmyrhysqslkcemnvgvylppkaaneklpvlywlsgltcneqnfitksgmqryaaehniivvapdtsprgshvadadrydlgqgagfylnatqapwnehykmydyirnelpdlvmhhfpatakksisghsmgglgalvlalrnpdeyvsvsafspivspsqvpwgqqafaaylaenkdawldydpvslisqgqrvaeimvdqglsddfyaeqlrtpnlekicqemniktliryhegydhsyyfvssfigehiayhanklnmr]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=frmB+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=frmB]]&nbsp;&nbsp;
 
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===Notes===
===Notes===
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FrmB also has p-nitrophenyl C2-C6 fatty acid ester and a-naphthyl acetate carboxylesterase activities in vitro. The frmRAB operon is negatively regulated by frmR, is induced by formaldehyde, and probably degrades formaldehyde. FrmB is 50% identical to P. denitrificans S-formylglutathione hydrolase. FrmB and YeiG are 50% identical paralogs; double mutant is formaldehyde sensitive; this may explain why an frmB single mutant did not have a formadehyde phenotype when tested on Biolog plates (Herring, 2004). The amino terminal half of FrmB is homologus to the C-terminal half of YieL. S9 peptidase family; YeiG or FrmB are not in MEROPS yet, but it has homologs.<ref name='LIB:EcoGene'/>




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==References==
==References==
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Latest revision as of 21:50, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

frmB

Gene Synonym(s)

ECK0352, b0355, JW0346, yaiM[1], yaiM

Product Desc.

S-formylglutathione hydrolase[2][3]

S-formylglutathione hydrolase, formaldehyde degradation[4]

Product Synonyms(s)

predicted esterase[1], B0355[2][1], YaiM[2][1], FrmB[2][1] , ECK0352, JW0346, yaiM, b0355

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): frmB[2]

Regulation/Activity
Quick Links



        

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Notes

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FrmB also has p-nitrophenyl C2-C6 fatty acid ester and a-naphthyl acetate carboxylesterase activities in vitro. The frmRAB operon is negatively regulated by frmR, is induced by formaldehyde, and probably degrades formaldehyde. FrmB is 50% identical to P. denitrificans S-formylglutathione hydrolase. FrmB and YeiG are 50% identical paralogs; double mutant is formaldehyde sensitive; this may explain why an frmB single mutant did not have a formadehyde phenotype when tested on Biolog plates (Herring, 2004). The amino terminal half of FrmB is homologus to the C-terminal half of YieL. S9 peptidase family; YeiG or FrmB are not in MEROPS yet, but it has homologs.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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