wrbA:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Standard Name |
wrbA |
|---|---|
| Gene Synonym(s) |
ECK0995, b1004, JW0989[1], JW0989 |
| Product Desc. |
NAD(P)H:quinone oxidoreductase[2][3]; Component of NAD(P)H:quinone oxidoreductase[3] NAD(P)H:quinone oxidoreductase, type IV NQO; may protect against oxidative stress; dimeric, binds one FMN per monomer[4] |
| Product Synonyms(s) |
predicted flavoprotein in Trp regulation[1], B1004[2][1], WrbA[2][1] , ECK0995, JW0989, b1004 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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Notes
WrbA was originally identified as a stationary phase TrpR-binding protein that affected the interaction of TrpR with its operator sites in vitro (Yang, 1993). However, subsequent experiments found similar effects with BSA, concluding that WrbA does not influence TrpR-operator binding in vitro (Grandori, 1998). Although WrbA may affect the association between Trp repressor and operators in stationary phase in vivo (Yang, 1993), this may be a non-specific effect. EcoArray search results indicate that wrbA transcripts are altered by rpoS, relA, trpA and trpR mutations, among others. wrbA is repressed by OxyS overexpression (Tjaden, 2006). otherPDB: 1ZWL(P.aeruginosa).[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.