sucB:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
<protect>
| Standard Name |
sucB |
|---|---|
| Gene Synonym(s) |
ECK0715, b0727, JW0716, lys, met[1] |
| Product Desc. |
SucB-S-succinyldihydrolipoate 2-oxoglutarate dehydrogenase, E2 component; dihydrolipoamide succinyltransferase; acid-inducible; yields succinyl-CoA and CO(2)[4] |
| Product Synonyms(s) |
dihydrolipoyl transsuccinase[1], B0727[2][1] , ECK0715, JW0716, b0727 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression |
transcription unit(s): sdhCDAB-sucABCD[2], OP00142, sdhCDAB, sucABCD[2], OP00143, suc |
| Regulation/Activity | |
| Quick Links |
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Notes
sucAB is a synthetic lethal with sucCD. Residues 104-153 is the E3(Lpd) component binding domain, called the peripheral subunit binding domain (PSBD). When the isolated 50 aa PSBD domain is produced as a protein it is called BBL, which is structuerd at low temperature and may be an example of a downhill protein folding (Packman, 1986; Garcia-Mira, 2002). This controversial topic, centered around experiments with a naphthyl-alanine derivative of BBL termed Naf-BBL, has a topic page with additional citations.[4]
References
- ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
