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References Suggestions


Standard Name


Gene Synonym(s)

ECK0715, b0727, JW0716, lys, met[1]

Product Desc.



2-oxoglutarate dehydrogenase, E2 component; dihydrolipoamide succinyltransferase; acid-inducible; yields succinyl-CoA and CO(2)[4]

Product Synonyms(s)

dihydrolipoyl transsuccinase[1], B0727[2][1] , ECK0715, JW0716, b0727

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): sdhCDAB-sucABCD[2], OP00142, sdhCDAB, sucABCD[2], OP00143, suc

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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sucAB is a synthetic lethal with sucCD. Residues 104-153 is the E3(Lpd) component binding domain, called the peripheral subunit binding domain (PSBD). When the isolated 50 aa PSBD domain is produced as a protein it is called BBL, which is structuerd at low temperature and may be an example of a downhill protein folding (Packman, 1986; Garcia-Mira, 2002). This controversial topic, centered around experiments with a naphthyl-alanine derivative of BBL termed Naf-BBL, has a topic page with additional citations.[4]


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  1. 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.