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References Suggestions


Standard Name


Gene Synonym(s)

ECK2498, b2502, JW2487[1], JW2487

Product Desc.


Component of exopolyphosphatase[2][3]

Exopolyphosphatase; inhibited by pppGpp and ppGpp, also has guanosine pentaphosphatase activity[4]

Product Synonyms(s)

exopolyphosphatase[1], B2502[2][1], Ppx[2][1] , ECK2498, JW2487, b2502

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): ppk-ppx[2]

Quick Links

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PDB structure from O157:H7 has identical sequence as K-12. Competitive ihibition of Ppx by pppGpp during amino acid (relA-dependent) and phosphate starvation (spoT-dependent) apparently causes a sharp increase in cellular polyphosphate (Kuroda, 1997).[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.