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References Suggestions


Standard Name


Gene Synonym(s)

ECK0053, b0052, JW0051[1], JW0051

Product Desc.

4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent[2][3]

4-hydroxythreonine-4-phosphate dehydrogenase; fourth step in pyridoxal 5-phosphate biosynthesis; isoniazid resistance; requires divalent cations and NAD(P)+[4]

Product Synonyms(s)

4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent[1], B0052[2][1], PdxA[2][1] , ECK0053, JW0051, b0052

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): imp-surA-pdxA[2], pdxA-rsmA[2], pdxA-ksgA, pdxA-rsmA-apaGH[2], pdxA-ksgA-apaG-apaH, surA-pdxA-rsmA-apaGH[2], surA-pdxA-ksgA-apaGH

Quick Links

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Converts 4-hydroxy-L-threonine phosphate (HTP) to 3-amino-2-oxopropyl phosphate.[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.