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References Suggestions


Standard Name


Gene Synonym(s)

ECK2492, b2496, JW5397, idaB, yfgE, dp[1][2]

Product Desc.

regulator of DnaA that prevents premature reinitiation of DNA replication[2][3]

Required for regulatory inactivation of DnaA; multicopy suppressor of dnaN(ts)[4]

Product Synonyms(s)

ATPase regulatory factor involved in DnaA inactivation[1], IdaB[2][1], Hda[2][1], YfgE[2][1], B2496[2][1], Dp[2][1] , ECK2492, idaB, JW5397, yfgE, b2496

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): hda[2]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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hda is a DnaA paralog. The interaction of Hda with DNA polymerase III (beta) is mediated via the hexapeptide sequence and it is this interaction that may lead to events that result in DnaA inactivation. Hda-ADP is the monomeric active form for promoting clamp-mediated DNA-ATP hydrolysis (Su'etsugu, 2008). Hda has a verified CTG start codon (Su'etsugu, 2008). otherPDB (S. amazonensis): 3BOS.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.