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References Suggestions


Standard Name


Gene Synonym(s)

ECK0440, b0446, JW0436[1], JW0436

Product Desc.


HMP-PP phosphatase; catalyzes hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP); MeO-HMP-PP and CF3-HMP-PP also serve as substrates for Cof; HAD18[4]

Product Synonyms(s)

thiamin pyrimidine pyrophosphate hydrolase[1], B0446[2][1], Cof[2][1] , ECK0440, JW0436, b0446

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): cof[2]

Quick Links

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Cloned cof complements fur deletion mutant for growth on succinate: this gene name and function have only been reported as an annotation in EMBL entry Z54355, Patzer, S.I. and Hantke, K., 1995. HAD superfamily. Additional substrates include: pyridoxal phosphate (PLP), FMN, 2-deoxyglucose-6-P; in vitro activities demonstrated by Kuznetsova et al. (2005, 2006).[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.